Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Therapeutic Effect of Echium Amoenum on Isoproterenol-Induced Heart Failure in Male Rat Publisher



Jafari H1 ; Imani A2 ; Keshavarz M2 ; Babaei H1 ; Esmaeili S3 ; Raeisabdollahi E4, 5 ; Mokaberinejad R1, 6
Authors
Show Affiliations
Authors Affiliations
  1. 1. Department of Traditional Medicine, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Applied Physiology Research Center, Qom Medical Sciences, Islamic Azad University, Qom, Iran
  5. 5. Department of Basic Medical Sciences, Faculty of Medicine, Qom Medical Sciences, Islamic Azad University, Qom, Iran
  6. 6. Traditional Medicine and Materia Medica Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Research Journal of Pharmacognosy Published:2024


Abstract

Background and objectives: Echium amoenum has shown anti-inflammatory and antioxidants properties and is suggested for heart disease in Persian medicine. Methods: To evaluate its cardioprotective effects, 50 male Wistar rats were divided into five groups: Control (normal saline), isoproterenol (negative control), and tliree experimental groups (E. amoenum aqueous extract with daily doses of 150, 300 and 450 mg/kg). All rats, except the control group, were administered isoproterenol (150 mg/kg subcutaneously), for two consecutive days to induce heart failure. From the third day until ninth, treatment groups received the extract by gavage. The animals rested for one week. On the 17th day, they were anesthetized; blood samples were collected after echocardiography to measure CK (creatine kinase), LDH (lactate dehydrogenase), troponin. NIDA (Malondialdehyde), NO (nitrogen oxide), superoxide dismutase (SOD) and glutathione peroxidase (GPX). Pathological specimens were collected from the heart. Results: Administration of 150, 300 and 450 mg/kg E. amoenum extract increased the ejection fraction significantly; fractional shortening increased significantly only at 300 mg/kg. The dose of 450 mg/kg decreased the CK-MB and troponin levels. All doses decreased LDH. Administration of 450 mg/kg extract increase SOD and GPX level compared to the control and isoproterenol group. In addition, 300 and 450 mg/kg extract resulted in a significant decrease in NO and MDA levels compared to the isoproterenol group. Echium amoenum (300 mg/kg) reduced the percentage of tissue fibrosis. Conclusion: Echium amoenum has a significant effect on the protection of heart failure induced by isoproterenol. © 2024, Iranian Society of Pharmacognosy. All rights reserved.
Related Docs
1. Impact of Polyphenols on Heart Failure and Cardiac Hypertrophy: Clinical Effects and Molecular Mechanisms, Frontiers in Cardiovascular Medicine (2023)