Calorie Restriction and Synbiotics Effect on Quality of Life and Edema Reduction in Breast Cancer-Related Lymphedema, a Clinical Trial

Calorie Restriction and Synbiotics Effect on Quality of Life and Edema Reduction in Breast Cancer-Related Lymphedema, a Clinical Trial Publisher Pubmed

Vafa S¹ ; Zarrati M¹ ; Malakootinejad M¹ ; Totmaj AS¹ ; Zayeri F² ; Salehi M³ ; Sanati V¹ ; Haghighat S⁴

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1. Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
2. Proteomics Research Center and Department of Biostatistics, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Biostatistics, School of Public Health, Health, Iran University of Medical Sciences, Tehran, Iran
4. Breast Cancer Research Center, Motamed Cancer Institute, ACECR, Tehran, Iran

Source: Breast Published:2020

Abstract

Background: Little evidence exists regarding the clinical value of synbiotics in the management of post-treatment complications of breast cancer especially breast cancer-related lymphedema (BCRL). This study aimed to investigate the effects of synbiotic supplementation along with calorie restriction on quality of life and edema volume in patients with BCRL. Methods: This randomized, placebo-controlled, clinical trial was conducted on 135 overweight and obese women with BCRL aged 18–65 years old. Participants were randomly allocated to receive a calorie-restricted diet plus 109 CFU synbiotic supplement (CRS group; n = 45) or placebo (CRP group; n = 45), daily for 10 weeks. Also, a control group (n = 45) with no intervention was included in the trial. All of the participants received Complete Decongestive Therapy for lymphedema treatment. The quality of life score, edema volume and body mass index (BMI) were measured at baseline and end of the trial. Results: A total of 121 subjects completed the trial. CRS group showed a significant decrease in the total quality of life score (P = 0.004), and it's psychosocial (P = 0.022) and functional (P = 0.002) domain scores, as well as edema volume (P = 0.002) and BMI (P < 0.001) in comparison to the control. However, there were no significant differences in changes in trial outcomes between the CRS and CRP groups. Conclusion: Synbiotic supplementation along with a low-calorie diet was effective in quality of life, edema volume, and BMI improvement; mostly due to low-calorie diet. It seems that adding a dietitian consultation on the lymphedema management strategy may provide a better result in lymphedema control. © 2020 The Author(s)

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Style	Citing Format
MLA	Vafa S, et al.. "Calorie Restriction and Synbiotics Effect on Quality of Life and Edema Reduction in Breast Cancer-Related Lymphedema, a Clinical Trial." Breast, vol. 54, no. , 2020, pp. 37-45.
APA	Vafa S, Zarrati M, Malakootinejad M, Totmaj AS, Zayeri F, Salehi M, Sanati V, Haghighat S (2020). Calorie Restriction and Synbiotics Effect on Quality of Life and Edema Reduction in Breast Cancer-Related Lymphedema, a Clinical Trial. Breast, 54(), 37-45.
Chicago	Vafa S, Zarrati M, Malakootinejad M, Totmaj AS, Zayeri F, Salehi M, Sanati V, Haghighat S. "Calorie Restriction and Synbiotics Effect on Quality of Life and Edema Reduction in Breast Cancer-Related Lymphedema, a Clinical Trial." Breast 54, no. (2020): 37-45.
Harvard	Vafa S et al. (2020) 'Calorie Restriction and Synbiotics Effect on Quality of Life and Edema Reduction in Breast Cancer-Related Lymphedema, a Clinical Trial', Breast, 54(), pp. 37-45.
Vancouver	Vafa S, Zarrati M, Malakootinejad M, Totmaj AS, Zayeri F, Salehi M, et al.. Calorie Restriction and Synbiotics Effect on Quality of Life and Edema Reduction in Breast Cancer-Related Lymphedema, a Clinical Trial. Breast. 2020;54():37-45.
BibTex	@article{ author = {Vafa S and Zarrati M and Malakootinejad M and Totmaj AS and Zayeri F and Salehi M and Sanati V and Haghighat S}, title = {Calorie Restriction and Synbiotics Effect on Quality of Life and Edema Reduction in Breast Cancer-Related Lymphedema, a Clinical Trial}, journal = {Breast}, volume = {54}, number = {}, pages = {37-45}, year = {2020} }
RIS	TY - JOUR AU - Vafa S AU - Zarrati M AU - Malakootinejad M AU - Totmaj AS AU - Zayeri F AU - Salehi M AU - Sanati V AU - Haghighat S TI - Calorie Restriction and Synbiotics Effect on Quality of Life and Edema Reduction in Breast Cancer-Related Lymphedema, a Clinical Trial JO - Breast VL - 54 IS - SP - 37 EP - 45 PY - 2020 ER -

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