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The Impact of Exosomes on Bone Health: A Focus on Osteoporosis Publisher Pubmed



Mehrvar A1 ; Akbari M2 ; Khosroshahi EM3, 5, 17 ; Nekavand M3, 5, 17 ; Mokhtari K7 ; Baniasadi M8 ; Aghababaian M10 ; Karimi M11 ; Amiri S12 ; Moazen A13 ; Maghsoudloo M14 ; Alimohammadi M15 ; Rahimzadeh P16 ; Farahani N2 Show All Authors
Authors
  1. Mehrvar A1
  2. Akbari M2
  3. Khosroshahi EM3, 5, 17
  4. Nekavand M3, 5, 17
  5. Mokhtari K7
  6. Baniasadi M8
  7. Aghababaian M10
  8. Karimi M11
  9. Amiri S12
  10. Moazen A13
  11. Maghsoudloo M14
  12. Alimohammadi M15
  13. Rahimzadeh P16
  14. Farahani N2
  15. Vaghar ME3, 5, 17
  16. Entezari M3, 5, 17
  17. Hashemi M3, 5, 17

Source: Pathology, research and practice Published:2024


Abstract

Osteoporosis is a widespread chronic condition. Although standard treatments are generally effective, they are frequently constrained by side effects and the risk of developing drug resistance. A promising area of research is the investigation of extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, which play a crucial role in bone metabolism. Exosomes, in particular, have shown significant potential in both the diagnosis and treatment of osteoporosis. EVs derived from osteoclasts, osteoblasts, mesenchymal stem cells, and other sources can influence bone metabolism, while exosomes from inflammatory and tumor cells may exacerbate bone loss, highlighting their dual role in osteoporosis pathology. This review offers a comprehensive overview of EV biogenesis, composition, and function in osteoporosis, focusing on their diagnostic and therapeutic potential. We examine the roles of various types of EVs and their cargo-proteins, RNAs, and lipids-in bone metabolism. Additionally, we explore the emerging applications of EVs as biomarkers and therapeutic agents, emphasizing the need for further research to address current challenges and enhance EV-based strategies for managing osteoporosis. Copyright © 2024 Elsevier GmbH. All rights reserved.
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