Nanosilver Based Anionic Linear Globular Dendrimer With a Special Significant Antiretroviral Activity

Nanosilver Based Anionic Linear Globular Dendrimer With a Special Significant Antiretroviral Activity Publisher Pubmed

Ardestani MS¹ ; Fordoei AS^{2, 3} ; Abdoli A² ; Ahangari Cohan R⁴ ; Bahramali G² ; Sadat SM² ; Siadat SD⁵ ; Moloudian H⁶ ; Nassiri Koopaei N⁷ ; Bolhasani A² ; Rahimi P² ; Hekmat S² ; Davari M² ; Aghasadeghi MR²

Show Affiliations

1. Department of Radiopharmacy, Tehran University of Medical Sciences, Tehran, Iran
2. Department of Hepatitis and AIDS, Pasteur Institute of Iran, Tehran, 13164, Iran
3. Department of Biology, College of Basic Sciences, Tehran Science and Research Branch, Islamic Azad University, Tehran, Iran
4. Virology Research Group, Department of Rabies, Pasteur Institute of Iran, Tehran, Iran
5. Department of Bacteriology, Pasteur Institute of Iran, Tehran, Iran
6. Pharmaceutical Quality Assurance Research Center, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Pharmaceutical Biotechnology, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Materials Science: Materials in Medicine Published:2015

Abstract

HIV is commonly caused to a very complicated disease which has not any recognized vaccine, so designing and development of novel antiretroviral agents with specific application of nanomedicine is a globally interested research subject worldwide. In the current study, a novel structure of silver complexes with anionic linear globular dendrimer was synthesized, characterized and then assessed against HIV replication pathway in vitro as well. The results showed a very good yield of synthesis (up to 70 %) for the nano-complex as well as a very potent significant (P < 0.05) antiretroviral activity with non-severe toxic effects in comparison with the Nevirapine as standard drug in positive control group. According to the present data, silver anionic linear globular dendrimers complex may have a promising future to inhibit replication of HIV viruse in clinical practice. © 2015, Springer Science+Business Media New York.

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Mehdi Shafee Ardestani (19)

Reza Faridi Majidi (2)

Style	Citing Format
MLA	Ardestani MS, et al.. "Nanosilver Based Anionic Linear Globular Dendrimer With a Special Significant Antiretroviral Activity." Journal of Materials Science: Materials in Medicine, vol. 26, no. 5, 2015, pp. -.
APA	Ardestani MS, Fordoei AS, Abdoli A, Ahangari Cohan R, Bahramali G, Sadat SM, Siadat SD, Moloudian H, Nassiri Koopaei N, Bolhasani A, Rahimi P, Hekmat S, Davari M, Aghasadeghi MR (2015). Nanosilver Based Anionic Linear Globular Dendrimer With a Special Significant Antiretroviral Activity. Journal of Materials Science: Materials in Medicine, 26(5), -.
Chicago	Ardestani MS, Fordoei AS, Abdoli A, Ahangari Cohan R, Bahramali G, Sadat SM, Siadat SD, et al.. "Nanosilver Based Anionic Linear Globular Dendrimer With a Special Significant Antiretroviral Activity." Journal of Materials Science: Materials in Medicine 26, no. 5 (2015): -.
Harvard	Ardestani MS et al. (2015) 'Nanosilver Based Anionic Linear Globular Dendrimer With a Special Significant Antiretroviral Activity', Journal of Materials Science: Materials in Medicine, 26(5), pp. -.
Vancouver	Ardestani MS, Fordoei AS, Abdoli A, Ahangari Cohan R, Bahramali G, Sadat SM, et al.. Nanosilver Based Anionic Linear Globular Dendrimer With a Special Significant Antiretroviral Activity. Journal of Materials Science: Materials in Medicine. 2015;26(5):-.
BibTex	@article{ author = {Ardestani MS and Fordoei AS and Abdoli A and Ahangari Cohan R and Bahramali G and Sadat SM and Siadat SD and Moloudian H and Nassiri Koopaei N and Bolhasani A and Rahimi P and Hekmat S and Davari M and Aghasadeghi MR}, title = {Nanosilver Based Anionic Linear Globular Dendrimer With a Special Significant Antiretroviral Activity}, journal = {Journal of Materials Science: Materials in Medicine}, volume = {26}, number = {5}, pages = {-}, year = {2015} }
RIS	TY - JOUR AU - Ardestani MS AU - Fordoei AS AU - Abdoli A AU - Ahangari Cohan R AU - Bahramali G AU - Sadat SM AU - Siadat SD AU - Moloudian H AU - Nassiri Koopaei N AU - Bolhasani A AU - Rahimi P AU - Hekmat S AU - Davari M AU - Aghasadeghi MR TI - Nanosilver Based Anionic Linear Globular Dendrimer With a Special Significant Antiretroviral Activity JO - Journal of Materials Science: Materials in Medicine VL - 26 IS - 5 SP - EP - PY - 2015 ER -

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