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Fabrication of a Novel Biosensor for Biosensing of Bisphenol a and Detection of Its Damage to Dna Publisher Pubmed



Jalalvand AR1 ; Haseli A1 ; Farzadfar F2 ; Goicoechea HC3
Authors
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Authors Affiliations
  1. 1. Research Center of Oils and Fats, Kermanshah University of Medical Sciences, Kermanshah, Iran
  2. 2. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Laboratorio de Desarrollo Analitico y Quimiometria (LADAQ), Catedra de Quimica Analitica I, Universidad Nacional del Litoral, Ciudad Universitaria, CC 242, Santa Fe, S3000ZAA, Argentina

Source: Talanta Published:2019


Abstract

In this work, a novel electrochemical biosensor has been fabricated based on step-by-step modification of a glassy carbon electrode (GCE) with methylene blue (MB)-DNA/multiwalled carbon nanotubes (MWCNTs)-chitosan (CS)/palladium nanoparticles (Pd NPs)/fullerene C60 (C60) for voltammetric and impedimetric detection of DNA damage induced by bisphenol A (BPA). Modifications applied to the GCE were characterized by cyclic voltammetry (CV), differential pulse voltammetry (DPV), electrochemical impedance spectroscopy (EIS) and scanning electron microscopy. The EIS and DPV responses of the biosensor were increased and decreased, respectively, by the DNA damage induced by BPA which led us to develop novel systems for detection of DNA damage. Our records confirmed that the biosensor was able to rapid and sensitive detection of DNA damage induced by BPA. Finally, according to the developed systems for detection of DNA damage, we have developed voltammetric and impedimetric methods for determination of BPA. © 2019 Elsevier B.V.
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