Coronally Advanced Flap With a Xenogeneic Collagen Matrix or an Rhpdgf-Bb Regenerative Approach for Bilateral Multiple Gingival Recessions: A Split-Mouth Clinical Feasibility Study Publisher Pubmed



Barootchi S ; Rodriguez M V ; Sabri H ; Manouchehri N ; Barootchi E ; Wang H L ; Tavelli L
Source: International Journal of Periodontics and Restorative Dentistry Published:2026

Abstract

This split-mouth trial investigated the efficacy of treating bilateral gingival recessions with either a xenogeneic cross-linked collagen matrix (CCM) or recombinant human platelet-derived growth factor-BB (rhPDGF-BB) with a bone allograft (AG). Ten patients were treated with a coronally advanced flap, either with CCM or rhPDGF-BB + AG. The primary outcome was percentage of mean root coverage (mRC) at 12 months. Additional outcomes included clinical and volumetric measurements; patient-reported outcome measures (PROMs) for pain, swelling, and esthetics; and ultrasonographic assessment of gingival thickness (GT) and position of the buccal bone. At 12 months, both groups showed significant improvements, with an mRC of 78.6% in the CCM group and 82.3% in the rhPDGF-BB + AG group. A 3D analysis of both groups showed comparable volumetric gain. CCM-treated sites displayed higher ultrasonographic echogenicity in GT (P < .01) than rhPDGF-BB + AG sites. The rhPDGF-BB + AG group showed greater reductions in the buccal bone dehiscence (mean: 2.03 mm; P < .01), less swelling during the first 3 days, and slightly greater mRC. CCM and rhPDGF-BB + AG were effective in treating multiple adjacent gingival recessions. CCM promotes greater gains in gingival thickness, while rhPDGF-BB + AG resulted in significantly less buccal bone. © 2026 BY QUINTESSENCE PUBLISHING CO, INC. PRINTING OF THIS DOCUMENT IS RESTRICTED TO PERSONAL USE ONLY. NO PART MAY BE REPRODUCED OR TRANSMITTED IN ANY FORM WITHOUT WRITTEN PERMISSION FROM THE PUBLISHER.