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Soluble Cd40 Ligand Derived From Serum Is Not Correlated With Early Ms Publisher Pubmed



Zahednasab H1 ; Siroos B2 ; Balood M3 ; Aleagha MSE3 ; Harirchian MH2
Authors
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Authors Affiliations
  1. 1. Institute of Biochemistry and Biophysics, University of Tehran, Tehran, Iran
  2. 2. Iranian Centre of Neurological Research, Department of Neurology Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Clinical Biochemistry, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran

Source: Multiple Sclerosis and Related Disorders Published:2017


Abstract

Background Soluble CD40 ligand (sCD154) is a proinflammatory and prothrombotic ligand belonging to the tumor necrosis factor family. It has been shown by a variety of studies that sCD154 is elevated in the serum of patients afflicted with system autoimmune diseases. The aim of our study was to address whether sCD154 is increased in disease affected by Multiple Sclerosis (MS). Methods Twenty MS patients who have been newly diagnosed as clinically definite multiple sclerosis (CDMS) along with twenty age and sex matched healthy individuals were recruited for this study. Serum cCD154 was measured by Enzyme-Linked Immunosorbent Assay (ELISA). Results The results showed no statistically meaningful difference between newly diagnosed MS patients (3.07 ng/ul±0.66) and control group (2.95 ng/ul±0.79; p=0.62) Conclusion Regarding our study, it seems that soluble CD40 ligand derived from serum is not correlated with early stage of MS disease. © 2017 Elsevier B.V.
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