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Reference Values for Lipid Profile in Iranian Children and Adolescents: The Caspian-V Study Publisher Pubmed



Azizisoleiman F1 ; Khoramdad M2 ; Heshmat R3 ; Ejtahed HS4 ; Motlagh ME5 ; Daniali SS6 ; Qorbani M7, 8 ; Kelishadi R6
Authors
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Authors Affiliations
  1. 1. School of Health, Arak University of Medical Sciences, Arak, Iran
  2. 2. Department of Epidemiology, School of Public Healthz, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pediatrics, Ahvaz Jundishapur, University of Medical Sciences, Ahvaz, Iran
  6. 6. Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-Communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran
  7. 7. Non-communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, 31485/56, Iran
  8. 8. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Lipids in Health and Disease Published:2020


Abstract

Background: We aimed to develop the age- A nd sex-specific reference values for lipid profile of Iranian pediatric population. Methods: Fasting lipid profiles of 3843 participants, aged 7 to 18 years, were extracted from a surveillance survey on Iranian children and adolescents living in 30 provinces across the country. Results: The mean (SD) age of participants was 12.3(3.1) years, and 52.3% of them were boys. Significant differences were observed between genders comparing the levels of triglyceride (TG) (P = 0.04), total cholesterol (TC) (P = 0.02), low-density lipoprotein-cholesterol (LDL-C) (P = 0.01), and non-high-density lipoprotein cholesterol (non-HDL-C) (P = 0.03). In both genders, TG levels increased with age in the 75th and higher percentiles. Among boys, TC showed a decreasing trend at all percentiles and all age groups. In girls, TC levels increased with age at all percentiles except for the 75th and 90th percentiles. Among boys, the levels of LDL-C and HDL-C decreased with age in all percentiles. However, LDL-C and HDL-C concentrations increased up to the 50th percentile in girls and then decreased with age. The non-HDL-C level decreased in the 50th and higher percentiles among boys and in the 90th and 95th percentiles among girls. The TG/HDL-C ratio increased with age at all percentiles in boys. In girls, TG/HDL-C ratio increased with age in the 50th and higher percentiles. Conclusions: Based on the observed differences, it seems necessary to determine age- A nd sex-specific cut-off values for lipid parameters of children and adolescents in different populations. © 2020 The Author(s).