First Evidence of the Presence of Adenovirus Type 8 in Myocardium of Patients With Severe Idiopathic Dilated Cardiomyopathy

First Evidence of the Presence of Adenovirus Type 8 in Myocardium of Patients With Severe Idiopathic Dilated Cardiomyopathy Publisher Pubmed

Hosseini SMJ¹ ; Mirhosseini SM² ; Taghian M³ ; Salehi M⁴ ; Farahani MM⁵ ; Bakhtiari F⁶ ; Ghasemipirbaluti M⁷ ; Motaghi E⁸

Show Affiliations

1. Molecular Biology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
2. Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Oral and Maxillofacial Surgery, School of Dentistry, Mazandaran University of Medical Sciences, Sari, Mazandaran, Iran
4. Cardiac Surgery Ward, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran
5. Atherosclerosis Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran
6. Department of Microbiology, Faculty of Advanced Science and Technologies, Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
7. Department of Immunology, Shahrekord University of Medical Sciences, Shahrekord, Iran
8. Department of Physiology and Pharmacology, School of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran

Source: Archives of Virology Published:2018

Abstract

Previous studies have detected adenovirus and cytomegalovirus (CMV) in cardiac tissue of patients with myocarditis. Therefore, in this study, we investigated the frequency of these viruses, which may be involved in the development of severe dilated cardiomyopathy (DCM). Myocardial tissue from of 23 cardiac transplant candidates with acute idiopathic DCM below the age of 40 years were analyzed by amplification of adenovirus and CMV DNA and subsequent sequencing. Adenovirus was detected in four (17.4%) and CMV in one (4.3%) of the patients. All controls were negative for the presence of both viruses. Our study shows that myocardial infection with adenovirus may play an important role in the pathogenesis of severe DCM and suggests that vaccination against adenovirus might be helpful in decreasing the prevalence of severe idiopathic DCM. This is the first study in which adenovirus type 8 has been detected in the hearts of patients with DCM. © 2018, Springer-Verlag GmbH Austria, part of Springer Nature.

Style	Citing Format
MLA	Hosseini SMJ, et al.. "First Evidence of the Presence of Adenovirus Type 8 in Myocardium of Patients With Severe Idiopathic Dilated Cardiomyopathy." Archives of Virology, vol. 163, no. 10, 2018, pp. 2895-2897.
APA	Hosseini SMJ, Mirhosseini SM, Taghian M, Salehi M, Farahani MM, Bakhtiari F, Ghasemipirbaluti M, Motaghi E (2018). First Evidence of the Presence of Adenovirus Type 8 in Myocardium of Patients With Severe Idiopathic Dilated Cardiomyopathy. Archives of Virology, 163(10), 2895-2897.
Chicago	Hosseini SMJ, Mirhosseini SM, Taghian M, Salehi M, Farahani MM, Bakhtiari F, Ghasemipirbaluti M, Motaghi E. "First Evidence of the Presence of Adenovirus Type 8 in Myocardium of Patients With Severe Idiopathic Dilated Cardiomyopathy." Archives of Virology 163, no. 10 (2018): 2895-2897.
Harvard	Hosseini SMJ et al. (2018) 'First Evidence of the Presence of Adenovirus Type 8 in Myocardium of Patients With Severe Idiopathic Dilated Cardiomyopathy', Archives of Virology, 163(10), pp. 2895-2897.
Vancouver	Hosseini SMJ, Mirhosseini SM, Taghian M, Salehi M, Farahani MM, Bakhtiari F, et al.. First Evidence of the Presence of Adenovirus Type 8 in Myocardium of Patients With Severe Idiopathic Dilated Cardiomyopathy. Archives of Virology. 2018;163(10):2895-2897.
BibTex	@article{ author = {Hosseini SMJ and Mirhosseini SM and Taghian M and Salehi M and Farahani MM and Bakhtiari F and Ghasemipirbaluti M and Motaghi E}, title = {First Evidence of the Presence of Adenovirus Type 8 in Myocardium of Patients With Severe Idiopathic Dilated Cardiomyopathy}, journal = {Archives of Virology}, volume = {163}, number = {10}, pages = {2895-2897}, year = {2018} }
RIS	TY - JOUR AU - Hosseini SMJ AU - Mirhosseini SM AU - Taghian M AU - Salehi M AU - Farahani MM AU - Bakhtiari F AU - Ghasemipirbaluti M AU - Motaghi E TI - First Evidence of the Presence of Adenovirus Type 8 in Myocardium of Patients With Severe Idiopathic Dilated Cardiomyopathy JO - Archives of Virology VL - 163 IS - 10 SP - 2895 EP - 2897 PY - 2018 ER -

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