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Plasma Changes of Branched-Chain Amino Acid in Patients With Esophageal Cancer Publisher



Taherizadeh M1 ; Khoshnia M2 ; Shams S3 ; Hesari Z4, 5 ; Joshaghani H4
Authors
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Authors Affiliations
  1. 1. Department of Biochemistry and Bio-physics, Metabolic Disorders Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  2. 2. Golestan Research Center of Gastroenter-ology & Hepatology, Golestan University of Medical Sciences, Gorgan, Golestan, Iran
  3. 3. Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan, Iran
  5. 5. Department of Laboratory Sciences, Faculty of Paramedicine, Golestan University of Medical Sciences, Gorgan, Iran

Source: Middle East Journal of Digestive Diseases Published:2021


Abstract

BACKGROUND Studies have indicated that branched amino acids play a crucial role in gene expression, protein metabolism, apoptosis, and restoration of hepatocytes and insulin resistance. This study aimed to compare the plasma levels of branched-chain amino acids in patients with esophageal cancer and normal individuals. METHODS Plasma levels of leucine and isoleucine of 37 patients with esophageal cancer and 37 healthy adults were investigated by high-pressure liquid chromatography. Data analysis was performed using SPSS (version 16) software, and t test was used to compare the plasma levels of branched-chain amino acids in the two groups. RESULTS In the patients group, the mean age ± SD was 63 ± 13.64 years, and 21 (56.8%) individuals were male. In the control group, the mean age ± SD was 64.24 ± 13.08 years, and 21 (54.1%) individuals were male. Plasma levels of leucine (37.68 ± 105) and isoleucine (22.43 ± 59.1) in patients with esophageal cancer were significantly reduced (p value of isoleucine:0.007, and leucine: 0.0001). CONCLUSION In the present study, the plasma levels of branched-chain amino acids in patients with esophageal cancer had changed. Evidence suggests that branched-chain amino acids are essential nutrients for cancer growth and are used by tumors in various biosynthetic pathways as energy sources. Thus, studies in this field can be useful in providing appropriate therapeutic approaches. © 2021 The Author(s).
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