Next Generation Sequencing in Clinical Oncology: Applications, Challenges and Promises: A Review Article



Shabani Azim F¹ ; Houri H² ; Ghalavand Z² ; Nikmanesh B^{3, 4}
Source: Iranian Journal of Public Health Published:2018

Abstract

Background: The aim of this mini-review is to highlight the potential applications of next-generation sequencing technology to the field of clinical oncology with respect to genetic diagnosis, cancer classification, predictive biomarkers and personalized medicine. Methods: Scientific databases were searched to collect relative data. Results: Effective systematic analysis of whole-genome sequence and whole-exome sequence of tumors, targeted genome profiling, transcriptome sequencing and tumor-normal comparisons can be performed using NGS in order to diagnosis of several types of cancer. Conclusion: NGS technology can be powerful enough to discover new and infrequent gene alterations, identify hereditary cancer mutation carriers and provide a reliable molecular portrait of wide range of cancers in a quick and cost-effective manner. © 2018, Iranian Journal of Public Health. All rights reserved.