Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Next Generation Sequencing in Clinical Oncology: Applications, Challenges and Promises: A Review Article



Shabani Azim F1 ; Houri H2 ; Ghalavand Z2 ; Nikmanesh B3, 4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Student Scientific Research Center, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Dept. of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Zoonosis Research Center, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Dept. of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran

Source: Iranian Journal of Public Health Published:2018

Abstract

Background: The aim of this mini-review is to highlight the potential applications of next-generation sequencing technology to the field of clinical oncology with respect to genetic diagnosis, cancer classification, predictive biomarkers and personalized medicine. Methods: Scientific databases were searched to collect relative data. Results: Effective systematic analysis of whole-genome sequence and whole-exome sequence of tumors, targeted genome profiling, transcriptome sequencing and tumor-normal comparisons can be performed using NGS in order to diagnosis of several types of cancer. Conclusion: NGS technology can be powerful enough to discover new and infrequent gene alterations, identify hereditary cancer mutation carriers and provide a reliable molecular portrait of wide range of cancers in a quick and cost-effective manner. © 2018, Iranian Journal of Public Health. All rights reserved.