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Reverse Expression Pattern of Sirtuin-1 and Histone Deacetylase-9 in Coronary Artery Disease Publisher Pubmed



Heidari L1 ; Ghaderian SMH1, 2 ; Bastami M3 ; Hosseini S4 ; Alipour Parsa S5 ; Heidari S6 ; Jafari H7 ; Sohrabifar N1 ; Pirhoushiaran M8
Authors
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Authors Affiliations
  1. 1. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medical Genetics, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. Department of Medical Genetics Ward, Imam Khomeini, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Cardiology, Cardiovascular Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Department of Immunology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Laboratory Sciences, Faculty of Paramedical Sciences, Jondishapour University of Medical Sciences, Ahvaz, Iran
  8. 8. Department of Medical Genetics, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Physiology and Biochemistry Published:2023


Abstract

Background: SIRT1 and HDAC 9 genes are related to inflammation and may contribute to the pathogenesis of coronary artery disease (CAD). We aimed to evaluate the expression level, methylation profile and polymorphisms of these genes in CAD patients. Methods: In this study, 50 CAD patients and 50 healthy individuals were recruited. The expression level change was evaluated using the TaqMan Real-Time PCR method. The methylation of genes promoter and genotyping of polymorphisms were evaluated by the HRM. Results: The expression level of SIRT1 was reduced while the HDAC9 expression level showed a significant elevation (p <.001). The SIRT1 gene promoter was hypomethylated and the HDAC9 gene promoter was hypermethylated in CAD patients. Also, CG + GG genotype in SIRT1 and both genotypes in the HDAC9 gene were associated with expression change. Conclusions: SIRT1 and HDAC9 genes, expression changes can be suggested as a potential biomarker for CAD detection. © 2020 Informa UK Limited, trading as Taylor & Francis Group.
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