The Role of Bax in the Apoptosis of Leishmania-Infected Macrophages

The Role of Bax in the Apoptosis of Leishmania-Infected Macrophages Publisher Pubmed

Aghaei M¹ ; Khanahmad H² ; Aghaei S³ ; Ali Nilforoushzadeh M⁴ ; Mohaghegh MA^{5, 6} ; Hejazi SH^{1, 7}

Show Affiliations

1. Skin Diseases and Leishmaniasis Research Center, Isfahan University of Medical Sciences, Isfahan, Iran
2. Department of Genetics and Molecular Biology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran
3. Cellular and Molecular Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
4. Skin and Stem Cell Research Center, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Laboratory Sciences, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
6. Health Sciences Research Center, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh, Iran
7. Skin Disease and Leishmaniasis Research Center, Department of Parasitology and Mycology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Microbial Pathogenesis Published:2020

Abstract

Background: Leishmania is a protozoan parasite that nests in macrophages and is responsible for the Leishmaniasis disease. In spite of different defense pathways, last strategy of macrophage for killing parasite is apoptosis process. By permeableizing the mitochondrial outer membrane (MOM). As breaching MOM releases apoptogenic factors like cytochrome-c which activate caspases that result in the destruction of the cell. In this review, we summarized the appropriate manuscripts regarding the bax includes, its different types and the effect of bax on the apoptosis of Leishmania and parasite-infected macrophages. Methods: Information about the role of BAX in the apoptosis of parasite-infected macrophage of recent articles were surveyed by searching computerized bibliographic database PubMed and Google Scholar entering the keywords BAX and leishmaniasis. Results: The common studies revealed Leishmania use different survival strategies for inhibiting macrophage apoptosis. As Leishmania by preventing homooligomerization or upregulating the anti-apoptotic molecule Bcl-2 can prohibits proteins of host-cell apoptosis such as Bax that is required for mitochondrial permeabilisation during apoptosis. Conclusion: With regard to the supportive role of bax in apoptosis and the preventive role of Leishmania in its function, it seems that expression of bax gene in parasite by technologies like transgenic or down regulating of anti-apoptotic molecule Bcl-2 by miRNA could be prompted the apoptosis process of infected-macrophages and inhibited extensive spread of Leishmania and the resulting lesions. © 2019 Elsevier Ltd

Related Docs

1. Tumor Suppressive Function of Microrna-192 in Acute Lymphoblastic Leukemia, Bosnian Journal of Basic Medical Sciences (2017)

Experts (# of related papers)

Shahrbano Rostami (1)

Style	Citing Format
MLA	Aghaei M, et al.. "The Role of Bax in the Apoptosis of Leishmania-Infected Macrophages." Microbial Pathogenesis, vol. 139, no. , 2020, pp. -.
APA	Aghaei M, Khanahmad H, Aghaei S, Ali Nilforoushzadeh M, Mohaghegh MA, Hejazi SH (2020). The Role of Bax in the Apoptosis of Leishmania-Infected Macrophages. Microbial Pathogenesis, 139(), -.
Chicago	Aghaei M, Khanahmad H, Aghaei S, Ali Nilforoushzadeh M, Mohaghegh MA, Hejazi SH. "The Role of Bax in the Apoptosis of Leishmania-Infected Macrophages." Microbial Pathogenesis 139, no. (2020): -.
Harvard	Aghaei M et al. (2020) 'The Role of Bax in the Apoptosis of Leishmania-Infected Macrophages', Microbial Pathogenesis, 139(), pp. -.
Vancouver	Aghaei M, Khanahmad H, Aghaei S, Ali Nilforoushzadeh M, Mohaghegh MA, Hejazi SH. The Role of Bax in the Apoptosis of Leishmania-Infected Macrophages. Microbial Pathogenesis. 2020;139():-.
BibTex	@article{ author = {Aghaei M and Khanahmad H and Aghaei S and Ali Nilforoushzadeh M and Mohaghegh MA and Hejazi SH}, title = {The Role of Bax in the Apoptosis of Leishmania-Infected Macrophages}, journal = {Microbial Pathogenesis}, volume = {139}, number = {}, pages = {-}, year = {2020} }
RIS	TY - JOUR AU - Aghaei M AU - Khanahmad H AU - Aghaei S AU - Ali Nilforoushzadeh M AU - Mohaghegh MA AU - Hejazi SH TI - The Role of Bax in the Apoptosis of Leishmania-Infected Macrophages JO - Microbial Pathogenesis VL - 139 IS - SP - EP - PY - 2020 ER -

Science Communicator Platform

Authors

Authors Affiliations

Abstract