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S-Allyl Cysteine Protects Against Lipopolysaccharide-Induced Acute Kidney Injury in the C57bl/6 Mouse Strain: Involvement of Oxidative Stress and Inflammation Publisher Pubmed



Khajevandkhazaei MR1 ; Azimi S2 ; Sedighnejad L2 ; Salari S1 ; Ghorbanpour A1 ; Baluchnejadmojarad T3 ; Mohsenimoghaddam P4 ; Khamse S4 ; Roghani M5
Authors
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Authors Affiliations
  1. 1. School of Medicine, Shahed University, Tehran, Iran
  2. 2. Department of Physiology, School of Medicine, Tehran, Iran
  3. 3. Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Department of Physiology, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Neurophysiology Research Center, Department of Physiology, Shahed University, Tehran, Iran

Source: International Immunopharmacology Published:2019


Abstract

Sepsis is a serious and life-threatening medical condition with a higher rate of patients' morbidity and mortality and with complications such as acute kidney injury (AKI). S-allyl cysteine (SAC) is the active constituent of the medicinal plant garlic (Allium sativum) with multiple beneficial effects including anti-inflammatory and antioxidant properties. In this research, we tried to determine the protective effect of SAC pretreatment in a mouse model of AKI. To induce AKI, lipopolysaccharide (LPS) was injected once (10 mg/kg, i.p.) and SAC was administered at doses of 25, 50, or 100 mg/kg (p.o.) 1 h before LPS. Treatment of LPS-challenged C56BL/6 animals with SAC lowered serum level of creatinine and blood urea nitrogen (BUN), partially restored renal oxidative stress-related biomarkers including malondialdehyde (MDA), glutathione (GSH), and activity of superoxide dismutase (SOD) and catalase in addition to improvement of mitochondrial membrane potential (MMP). Furthermore, SAC was capable to bring renal nuclear factor-kappaB (NF-κB), nuclear factor (erythroid-derived 2)-like 2 (Nrf2), toll-like receptor 4 (TLR4), cyclooxygenase-2 (COX2), tumor necrosis factor α (TNFα), interleukin-1β (IL-1β), interleukin-6 (IL-6), Annexin V, and DNA fragmentation partially back to their control levels. Additionally, SAC pretreatment was capable to exert a protective effect, as shown histologically by lower tubular injury and pathologic changes in the kidney. In summary, SAC is capable to alleviate LPS-induced AKI through mitigation of renal oxidative stress, inflammation, and apoptosis in addition to preservation of mitochondrial integrity and its favorable effect exhibits a dose-dependent pattern. © 2019 Elsevier B.V.
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