Association of Ace Gene Insertion/Deletion Polymorphism With Suicidal Attempt in an Iranian Population

Association of Ace Gene Insertion/Deletion Polymorphism With Suicidal Attempt in an Iranian Population Publisher Pubmed

Ghorbani E¹ ; Mohammadi M² ; Malakouti SK³ ; Mohammadikangarani H⁴ ; Abdollahi E¹ ; Torab M¹ ; Rahimimoghaddam P¹

Show Affiliations

1. Department of Pharmacology, School of Medicine, Iran University of Medical Sciences, Hemmat Highway, Tehran, 1449614525, Iran
2. School of Pharmacy, Azad University of Medical Sciences, Tehran, Iran
3. Mental Health Research Center, Tehran Institute of Psychiatry-School of Behavioral Sciences and Mental Health, Iran University of Medical Sciences, Tehran, Iran
4. Baharloo Hospital, Tehran University of Medical Sciences, Tehran, Iran

Source: Biochemical Genetics Published:2021

Abstract

Deregulation of the renin–angiotensin system (RAS) plays an important role in suicide. Angiotensin converting enzyme (ACE) gene is a key component in this system. The relationship between insertion/deletion (I/D) polymorphism of ACE gene with suicide attempt (SA) is controversial. According to previous studies, allele D in this polymorphism has been considered as a potential risk factor for suicide. However, no study has been conducted in Iran to investigate this matter. This case–control study has focused on investigating the association of ACE I/D polymorphism (rs1799752) with SA in an Iranian population. The frequency of genotypes was 14% for II, 55% for ID, and 31% for DD in the case group (100 persons), and 18% for II, 74% for ID, and 8% for DD in control group (100 persons). Results show there was a significant difference in the distribution of ACE I/D polymorphism genotypes in men with SA compared to controls, as well as in women with SA compared to controls. Also, there was a significant association between DD genotype and the risk of SA compared to II genotype as reference. The severity of depression was significantly different between DD and II genotypes in SA group. According to the results, we suggest that the presence of DD genotype is possibly associated with an increased risk of SA. Maybe part of that is related to severity of depression in DD genotypes carriers of ACE I/D polymorphism. © 2020, Springer Science+Business Media, LLC, part of Springer Nature.

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Style	Citing Format
MLA	Ghorbani E, et al.. "Association of Ace Gene Insertion/Deletion Polymorphism With Suicidal Attempt in an Iranian Population." Biochemical Genetics, vol. 59, no. 1, 2021, pp. 31-41.
APA	Ghorbani E, Mohammadi M, Malakouti SK, Mohammadikangarani H, Abdollahi E, Torab M, Rahimimoghaddam P (2021). Association of Ace Gene Insertion/Deletion Polymorphism With Suicidal Attempt in an Iranian Population. Biochemical Genetics, 59(1), 31-41.
Chicago	Ghorbani E, Mohammadi M, Malakouti SK, Mohammadikangarani H, Abdollahi E, Torab M, Rahimimoghaddam P. "Association of Ace Gene Insertion/Deletion Polymorphism With Suicidal Attempt in an Iranian Population." Biochemical Genetics 59, no. 1 (2021): 31-41.
Harvard	Ghorbani E et al. (2021) 'Association of Ace Gene Insertion/Deletion Polymorphism With Suicidal Attempt in an Iranian Population', Biochemical Genetics, 59(1), pp. 31-41.
Vancouver	Ghorbani E, Mohammadi M, Malakouti SK, Mohammadikangarani H, Abdollahi E, Torab M, et al.. Association of Ace Gene Insertion/Deletion Polymorphism With Suicidal Attempt in an Iranian Population. Biochemical Genetics. 2021;59(1):31-41.
BibTex	@article{ author = {Ghorbani E and Mohammadi M and Malakouti SK and Mohammadikangarani H and Abdollahi E and Torab M and Rahimimoghaddam P}, title = {Association of Ace Gene Insertion/Deletion Polymorphism With Suicidal Attempt in an Iranian Population}, journal = {Biochemical Genetics}, volume = {59}, number = {1}, pages = {31-41}, year = {2021} }
RIS	TY - JOUR AU - Ghorbani E AU - Mohammadi M AU - Malakouti SK AU - Mohammadikangarani H AU - Abdollahi E AU - Torab M AU - Rahimimoghaddam P TI - Association of Ace Gene Insertion/Deletion Polymorphism With Suicidal Attempt in an Iranian Population JO - Biochemical Genetics VL - 59 IS - 1 SP - 31 EP - 41 PY - 2021 ER -

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