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Coumarin-1,2,3-Triazole Hybrid Derivatives: Green Synthesis and Dft Calculations Publisher



Nouraie P1 ; Moradi Dehaghi S1 ; Foroumadi A2, 3
Authors
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Authors Affiliations
  1. 1. Department of Chemistry, Tehran North Branch, Islamic Azad University, Tehran, Iran
  2. 2. Drug Design and Development Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Medicinal Chemistry, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran

Source: Synthetic Communications Published:2019


Abstract

A series of new 1,2,3-triazole-coumarin hybrid system are synthesized from the click reaction between 3-azido coumarin and different aromatic terminal alkyne derivatives in a green manner. All compounds are characterized by IR, NMR and UV–VIS spectroscopy. The experimental observations are further supported by DFT computational studies to investigate the effect of substituents at para position in these compounds. © 2019, © 2019 Taylor & Francis Group, LLC.