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Sex and Age Differences in Inflammatory Bowel Disease Patients; a Nationwide Study Based on Iranian Registry of Crohn’S and Colitis (Ircc) Publisher Pubmed



Khanmohammadi S1, 2 ; Sheidaei A3 ; Alatab S4 ; Tabatabaeimalazy O1, 5 ; Vahedi H4 ; Mansourghanaei F6 ; Fakheri H7 ; Sheikhesmaeili F8 ; Sadeghi A4 ; Sima AR9 ; Anushiravan A4 ; Yazdanbod A10 ; Moosavy SH11 ; Maleki I7 Show All Authors
Authors
  1. Khanmohammadi S1, 2
  2. Sheidaei A3
  3. Alatab S4
  4. Tabatabaeimalazy O1, 5
  5. Vahedi H4
  6. Mansourghanaei F6
  7. Fakheri H7
  8. Sheikhesmaeili F8
  9. Sadeghi A4
  10. Sima AR9
  11. Anushiravan A4
  12. Yazdanbod A10
  13. Moosavy SH11
  14. Maleki I7
  15. Vosooghinia H12
  16. Malekzadeh M4
  17. Malekzadeh R4
Show Affiliations
Authors Affiliations
  1. 1. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Epidemiology and Biostatics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Digestive Disease Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  6. 6. Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences, Rasht, Iran
  7. 7. Gut and Liver Research Center, Mazandaran University of Medical Sciences, Sari, Iran
  8. 8. Liver and Digestive Research Center, Kurdistan University of Medical Sciences, Sanandaj, Iran
  9. 9. Sasan Alborz Biomedical Research Center, Masoud Gastroenterology and Hepatology Center, Tehran, Iran
  10. 10. Gastroenterology and Hepatology Department, Digestive Diseases Research Center, Ardabil University of Medical Sciences, Ardabil, Iran
  11. 11. Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
  12. 12. Gastroenterology and Hepatology Department, Faculty of Medicine, Ghaem Hospital, Mashhad, Iran

Source: PLoS ONE Published:2024


Abstract

Background Despite the rising prevalence of Inflammatory Bowel Disease (IBD), age and sex differences in its outcomes remain understudied. We investigated age and sex differences in IBD patients using a nationwide study in Iran, the Iranian Registry of Crohn’s and Colitis (IRCC). Methods The IRCC is a national registry that gathered information on adult IBD patients since 2017. The collected data included demographic information, medication history, disease activity, comorbidities, diagnosis age, prognosis, the extent of ulcerative colitis (UC), Crohn’s disease (CD) location, and extraintestinal manifestations. The statistical methods included the independent Student’s t-test, Chi-square test, and binary logistic regression, using R version 4.2.2. Results Among the 9,392 IBD patients, 7,496 (3,600 females) and 1,896 (808 females) had UC and CD, respectively. Sex difference showed higher odds of active disease in the past six months in male CD patients (OR 1.24 [95%CI 1.03, 1.49]) vs. females, but in male UC patients, the OR was 0.85 [0.78, 0.93]. Severe disease was less likely in CD patients aged 19–59 and >60 vs. <18. Similarly, UC patients <18 had lower odds of severe disease vs. those aged 19–59 and >60. Conclusions This study emphasizes the importance of understanding age and sex differences in IBD outcomes. These findings contribute to the ongoing global discussion on IBD management and facilitate the development of targeted interventions and personalized care. © 2024 Khanmohammadi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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