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Genetic of Alzheimer's Disease: A Narrative Review Article



Khanahmadi M1 ; Farhud DD2, 3 ; Malmir M4
Authors
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Authors Affiliations
  1. 1. Dept. of Clinical Psychology, Allame Tabataba’i University, Tehran, Iran
  2. 2. School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Dept. of Basic Sciences, Iranian Academy of Medical Sciences, Tehran, Iran
  4. 4. Dept. of Exceptional Children Psychology, Science and Research Branch, Islamic Azad University, Tehran, Iran

Source: Iranian Journal of Public Health Published:2015

Abstract

Background: Alzheimer's disease (AD) is one of the most common problems for old peoples. Etiology of AD is not clear, but genetic factors play a major role in determining a person's risk to develop AD. Twin and family studies confirm that AD has a genetic basis.AD genetics has been split into two broad categories: early-onset and late-onset. EO-AD cases are inherited in an autosomal dominant pattern. In this form, dominant mutations in genes like APP, PSEN-1 and PSEN-2 associated with AD. This study aimed to consider the role of genetic in AD. Method: At the first, most of the references in relation with genetic basis of AD searched from the following websites: PubMed, Science direct, Wiley & Sons (1995-2014). Then, the most common genes and their affects described briefly. Results: Aging is the most obvious risk factor for developing AD. There is a genetic basis for AD, of course this relation is not complete but it is significant. Conclusion: More than thousand genes studied in relation with Alzheimer's disease. Against the improvements in understanding different aspects of AD, the accurate genetic foundation of AD remain unclear. © 2015 Iranian Journal of Public Health. All Rights Reserved.
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