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Treatment-Related Complications in Childhood Acute Lymphoblastic Leukemia: Results of Medical Research Council Ukall X Publisher



Shahverdi E1 ; Karami P2 ; Tavakoli F3 ; Maki M4 ; Moazzami M5 ; Feizi F6 ; Salamati P7 ; Lotfipour A7 ; Ehsani MA7
Authors
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Authors Affiliations
  1. 1. Department of Cardiology, Angiology and Sleep Medicine, Bonifatius Hospital Lingen, Lingen, Germany
  2. 2. Department of Otorhinolaryngology-Head and Neck Surgery, Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Hematopoietic Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Department of Nursing and Midwifery, Falavarjan Branch, Islamic Azad University, Isfahan, Iran
  5. 5. Department of Pediatrics, Firouzgar Hospital, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Laboratory Hematology and Blood Bank, School of Allied Medical Sciences, Shahid Beheshi University of Medical Science, Tehran, Iran
  7. 7. Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran

Source: Middle East Journal of Cancer Published:2020


Abstract

Background: Acute lymphoblastic leukemia (ALL) is a heterogeneous group of lymphoid neoplasms resulting from the proliferation of malignant lymphoid cells. The aim of this study was to evaluate treatment-related complications in children with ALL receiving the Medical Research Council (MRC) UKALL X protocol. Methods: In this retrospective cross-sectional study, children with ALL receiving the MRC UKALL X protocol from 2008 to 2015 in Bahrami University Hospital, Iran, were enrolled. The clinical and morphological features were analysed and treatment-related complications were assessed. Results: Out of 67 children with ALL receiving the MRC UKALL X protocol, 44 (65.6 %) were boys and 23 (34.4%) were girls. Seven patients (10.7%) relapsed in the three years of diagnosis, and 50 children (74.6%) had an overall survival of three years. Average age in three-year-survival group and mortality group was 6.92 (SD: 3.96) and 6.35 (SD: 7.47), respectively (P= 0.38). Conclusion: Overall survival and relapse rates in this study confirm that this protocol is an appropriate treatment strategy. © 2020, Shiraz University of Medical Sciences. All rights reserved.