Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Collaborative Outcomes Study on Health and Functioning During Infection Times (Coh-Fit): Global and Risk-Group Stratified Course of Well-Being and Mental Health During the Covid-19 Pandemic in Adolescents Publisher Pubmed



Solmi M1, 2, 3, 4, 5 ; Thompson T6 ; Cortese S4 ; Estrade A3, 7 ; Agorastos A8 ; Radua J3, 9, 10 ; Dragioti E11, 12 ; Vancampfort D13 ; Thygesen LC14 ; Aschauer H15 ; Schlogelhofer M15 ; Aschauer E15 ; Schneeberger AA16 ; Huber CG17, 18 Show All Authors
Authors
  1. Solmi M1, 2, 3, 4, 5
  2. Thompson T6
  3. Cortese S4
  4. Estrade A3, 7
  5. Agorastos A8
  6. Radua J3, 9, 10
  7. Dragioti E11, 12
  8. Vancampfort D13
  9. Thygesen LC14
  10. Aschauer H15
  11. Schlogelhofer M15
  12. Aschauer E15
  13. Schneeberger AA16
  14. Huber CG17, 18
  15. Hasler G19
  16. Conus P20
  17. Do Cuenod KQ20
  18. Von Kanel R21
  19. Arrondo G10, 22
  20. Fusarpoli P3, 23, 24
  21. Gorwood P25, 26
  22. Llorca PM27
  23. Krebs MO26, 28
  24. Scanferla E25
  25. Kishimoto T29
  26. Rabbani G30
  27. Skoniecznazydecka K31
  28. Brambilla P32, 33
  29. Favaro A34
  30. Takamiya A29
  31. Zoccante L35
  32. Colizzi M36
  33. Bourgin J37
  34. Kaminski K38
  35. Moghadasin M39
  36. Seedat S40
  37. Matthews E41
  38. Wells J41
  39. Vassilopoulou E42
  40. Gadelha A43
  41. Su KP44, 45
  42. Kwon JS46
  43. Kim M47
  44. Lee TY48
  45. Papsuev O49
  46. Mankova D50
  47. Boscutti A51
  48. Gerunda C34
  49. Saccon D52
  50. Righi E53
  51. Monaco F54
  52. Croatto G55
  53. Cereda G32
  54. Demurtas J53
  55. Brondino N24
  56. Veronese N56
  57. Enrico P32
  58. Politi P24
  59. Ciappolino V57, 58
  60. Pfennig A59
  61. Bechdolf A5
  62. Meyerlindenberg A60
  63. Kahl KG61
  64. Domschke K62
  65. Bauer M59
  66. Koutsouleris N63
  67. Winter S5
  68. Borgwardt S64
  69. Bitter I65
  70. Balazs J66, 67
  71. Czobor P65
  72. Unoka Z65
  73. Mavridis D12
  74. Tsamakis K3
  75. Bozikas VP8
  76. Tunvirachaisakul C68
  77. Maes M68
  78. Rungnirundorn T68
  79. Supasitthumrong T68
  80. Haque A30
  81. Brunoni AR69
  82. Costardi CG43
  83. Schuch FB70, 71, 72
  84. Polanczyk G69
  85. Luiz JM73
  86. Fonseca L43
  87. Aparicio LV69
  88. Valvassori SS73
  89. Nordentoft M74
  90. Vendsborg P75
  91. Hoffmann SH14
  92. Sehli J76
  93. Sartorius N77
  94. Heuss S78
  95. Guinart D79, 80
  96. Hamilton J81
  97. Kane J82
  98. Rubio J82
  99. Sand M83
  100. Koyanagi A84
  101. Solanes A9
  102. Andreubernabeu A85
  103. San Jose Caceres A85
  104. Arango C85
  105. Diazcaneja CM85
  106. Hidalgomazzei D9
  107. Vieta E9
  108. Gonzalezpenas J85
  109. Fortea L9
  110. Parellada M85
  111. Fullana MA9
  112. Verdolini N9, 86
  113. Andrlikova E50
  114. Janku K50
  115. Millan MJ87
  116. Honciuc M27
  117. Moniuszkomalinowska A38
  118. Loniewski I31, 88
  119. Samochowiec J31
  120. Marlicz M31
  121. Sowa P38
  122. Marlicz W31, 90
  123. Spies G40
  124. Stubbs B3
  125. Firth J91
  126. Sullivan S92
  127. Darcin AE93
  128. Aksu H94
  129. Dilbaz N95
  130. Noyan O95
  131. Kitazawa M29
  132. Kurokawa S29
  133. Tazawa Y29
  134. Anselmi A7
  135. Cracco C7
  136. Machado AI7
  137. Estrade N7
  138. De Leo D96
  139. Curtis J97
  140. Berk M98
  141. Carvalho AF98
  142. Ward P99
  143. Teasdale S99
  144. Rosenbaum S99
  145. Marx W98
  146. Horodnic AV100
  147. Oprea L100
  148. Alexinschi O101
  149. Ifteni P102
  150. Turliuc S100
  151. Ciuhodaru T103
  152. Bolos A100
  153. Matei V104
  154. Nieman DH105
  155. Sommer I106
  156. Van Os J107
  157. Van Amelsvoort T108
  158. Sun CF45, 109
  159. Guu TW45, 65, 110
  160. Jiao C111
  161. Zhang J111
  162. Fan J111
  163. Zou L111
  164. Yu X112
  165. Chi X111
  166. De Timary P113, 114
  167. Van Winkel R13
  168. Ng B115
  169. Pena E115
  170. Arellano R115
  171. Roman R115
  172. Sanchez T115
  173. Movina L49
  174. Morgado P116, 117
  175. Brissos S118
  176. Aizberg O119
  177. Mosina A120
  178. Krinitski D121
  179. Mugisha J122
  180. Sadeghibahmani D18, 123
  181. Sheybani F124
  182. Sadeghi M125
  183. Hadi S39
  184. Brand S17, 18, 125, 126, 127
  185. Errazuriz A128
  186. Crossley N128
  187. Ristic DI129
  188. Lopezjaramillo C130
  189. Efthymiou D131
  190. Kuttichira P132
  191. Kallivayalil RA133
  192. Javed A134
  193. Afridi MI135
  194. James B136
  195. Sebakahomen OJ137
  196. Fiedorowicz J1, 2
  197. Daskalakis J138
  198. Yatham LN139
  199. Yang L140
  200. Okasha T141
  201. Dahdouh A142
  202. Tiihonen J10, 143
  203. Shin JI144
  204. Lee J145
  205. Mhalla A146
  206. Gaha L146
  207. Brahim T146
  208. Altynbekov K147
  209. Negay N147
  210. Nurmagambetova S147
  211. Jamei YA148
  212. Weiser M149
  213. Correll CU5, 79, 82
Show Affiliations
Authors Affiliations
  1. 1. University of Ottawa and The Ottawa Hospital, Ottawa, Canada
  2. 2. Ottawa Hospital Research Institute (OHRI), Ottawa, Canada
  3. 3. King's College London, London, United Kingdom
  4. 4. University of Southampton, Southampton, United Kingdom
  5. 5. Charite Universitatsmedizin Berlin, Berlin, Germany
  6. 6. University of Greenwich, London, United Kingdom
  7. 7. Universidad Catolica del Uruguay, Montevideo, Uruguay
  8. 8. Aristotle University of Thessaloniki, Thessaloniki, Greece
  9. 9. University of Barcelona, Barcelona, Spain
  10. 10. Karolinska Institutet in Stockholm, Sweden
  11. 11. Linkoping University, Linkoping, Sweden
  12. 12. University of Ioannina, Ioannina, Greece
  13. 13. Katholieke Universiteit Leuven (KU Leuven), Leuven, Belgium
  14. 14. University of Southern Denmark, Denmark
  15. 15. BioPsyC - Biopsychosocial Corporation, Vienna, Austria
  16. 16. University of California San Diego, CA, United States
  17. 17. University of Basel, Basel, Switzerland
  18. 18. Universitare Psychiatrische Kliniken Basel (UPK), Basel, Switzerland
  19. 19. University of Fribourg, Fribourg, Switzerland
  20. 20. University of Lausanne, Lausanne, Switzerland
  21. 21. University of Zurich, Switzerland
  22. 22. University of Navarra in Pamplona, Spain
  23. 23. South London and Maudsley NHS Foundation Trust, London, United Kingdom
  24. 24. University of Pavia, Pavia, Italy
  25. 25. Universite Paris Cite, Paris, France
  26. 26. Institute de Psychiatrie et Neuroscience de Paris, Paris, France
  27. 27. Universite Clermont Auvergne, Clermont-Ferrand, France
  28. 28. Universite de Paris, Paris, France
  29. 29. Keio University in Tokyo, Tokyo, Japan
  30. 30. National Foundation of Mental Health of Bangladesh, Bangladesh
  31. 31. Pomeranian Medical University in Szczecin, Szczecin, Poland
  32. 32. University of Milan, Milan, Italy
  33. 33. Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy
  34. 34. University of Padua, Padua, Italy
  35. 35. UOC Infanzia, Adolescenza, Famiglia e Consultori, Verona, Italy
  36. 36. University of Udine, Italy
  37. 37. GHNE, France
  38. 38. Medical University of Bialystok, Bialystok, Poland
  39. 39. Kharazmi University, Tehran, Iran
  40. 40. Stellenbosch University, South Africa
  41. 41. South East Technological University in Waterford, Ireland
  42. 42. University of Nicosia, Nicosia, Cyprus
  43. 43. Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  44. 44. An-Nan Hospital in Tainan, Taiwan
  45. 45. China Medical University Hospital in Taichung, Taiwan
  46. 46. Seoul National University College of Medicine, Seoul, South Korea
  47. 47. Seoul National University Hospital, Seoul, South Korea
  48. 48. Pusan National University Yangsan Hospital, Yangsan, South Korea
  49. 49. Moscow Research Institute of Psychiatry, Moscow, Russian Federation
  50. 50. National Institute of Mental Health in Klecany, Czech Republic
  51. 51. UTHealth in Houston, United States
  52. 52. AULSS4 Veneto Orientale, Italy
  53. 53. University of Modena and Reggio Emilia in Modena, Italy
  54. 54. ASL Salerno and the European Biomedical Research Institute of Salerno (EBRIS) in Salerno, Italy
  55. 55. University of Padova, Padova, Italy
  56. 56. University of Palermo, Palermo, Italy
  57. 57. Azienda Ospedaliero-Universitaria Ss
  58. 58. Antonio e Biagio e Cesare Arrigo, Alessandria, Italy
  59. 59. Technische Universitat Dresden, Dresden, Germany
  60. 60. Heidelberg University, Germany
  61. 61. Hannover Medical School, Germany
  62. 62. University of Freiburg, Freiburg, Germany
  63. 63. Ludwig-Maximilians-University of Munich, Munich, Germany
  64. 64. University of Lubeck, Lubeck, Germany
  65. 65. Semmelweis University, Budapest, Hungary
  66. 66. Eotvos Lorand University, Budapest, Hungary
  67. 67. Bjorknes University College, Oslo, Norway
  68. 68. Chulalongkorn University, Thailand
  69. 69. Universidade de Sao Paulo, Sao Paulo, Brazil
  70. 70. Universidade Federal de Santa Maria, RS, Santa Maria, Brazil
  71. 71. Universidad Autonoma de Chile, Providencia, Chile
  72. 72. Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
  73. 73. Universidade do Extremo Sul Catarinense, SC, Criciuma, Brazil
  74. 74. University of Copenhagen, Copenhagen, Denmark
  75. 75. Psykiatrifonden, Copenhagen, Denmark
  76. 76. Le Jolimont Psychiatry and Psychotherapy, Fribourg, Switzerland
  77. 77. Association for the Improvement of Mental Health Programmes (AMH), Switzerland
  78. 78. FHNW University of Applied Sciences and Arts Northwestern Switzerland, Switzerland
  79. 79. Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, New York, United States
  80. 80. Universitat Autonoma de Barcelona, Barcelona, Spain
  81. 81. University of Texas Health Science Center, Houston, United States
  82. 82. Zucker Hillside Hospital, Northwell Health, and the Feinstein Institutes for Medical Research, New York
  83. 83. S2 Consulting LLC
  84. 84. Parc Sanitari Sant Joan de Deu, Barcelona, Spain
  85. 85. Hospital General Universitario Gregorio Maranon, Madrid, Spain
  86. 86. Mental Health Center of Perugia, Italy
  87. 87. Glasgow University, Glasgow, United Kingdom
  88. 88. Sanprobi Sp. z o.o. Sp. k, Poland
  89. 89. University of Bialystok, Bialystok, Poland
  90. 90. Centre for Digestive Diseases Endoklinika, Szczecin, Poland
  91. 91. University of Manchester, United Kingdom
  92. 92. University of Bristol, Bristol, United Kingdom
  93. 93. Istanbul Topkapi University, Istanbul, Turkey
  94. 94. Adnan Menderes University Department of Child and Adolescent Psychiatry, Aydin, Turkey
  95. 95. Uskudar University, Istanbul, Turkey
  96. 96. Griffith University, South East Queensland, Australia
  97. 97. Mindgardens Neuroscience Network, Sydney, Australia
  98. 98. Deakin University, Victoria, Australia
  99. 99. UNSW Sydney, Sydney, Australia
  100. 100. University of Medicine and Pharmacy Grigore T. Popa, Iasi, Romania
  101. 101. Institute of Psychiatry “Socola”, Iasi, Romania
  102. 102. Transilvania University of Brasov, Brasov, Romania
  103. 103. Emergency Hospital “Nicolae Oblu”, Iasi, Romania
  104. 104. University of Medicine and Pharmacy “Carol Davila” Bucharest, Bucharest, Romania
  105. 105. Amsterdam University Medical Centers, Amsterdam, Netherlands
  106. 106. University Medical Center Groningen, Groningen, Netherlands
  107. 107. Utrecht University Medical Centre, Utrecht, Netherlands
  108. 108. Maastricht University, Maastricht, Netherlands
  109. 109. Carilion Clinic Virginia Tech Carilion School of Medicine, Roanoke, VA, United States
  110. 110. China Medical University Beigang Hospital, Taiwan
  111. 111. Shenzhen University, Shenzhen, China
  112. 112. Peking University Institute of Mental Health, Pekin, China
  113. 113. UCLouvain, Brussels, Belgium
  114. 114. Cliniques Universitaires Saint-Luc, Brussels, Belgium
  115. 115. Asociacion Psiquiatrica Mexicana, Mexico
  116. 116. University of Minho, Braga/Guimaraes, Portugal
  117. 117. ICVS/3B's - PT Government Associate Laboratory, Braga/Guimaraes, Portugal
  118. 118. Lisbon's Psychiatric Hospital Centre, Portugal
  119. 119. Belarusian Medical Academy of Postgraduate Education, Belarus
  120. 120. Clienia AG, Switzerland
  121. 121. Integrated Psychiatry Winterthur (IPW), Switzerland
  122. 122. Kyambogo University, Kampala, Uganda
  123. 123. Stanford University, CA, United States
  124. 124. Mashhad University of Medical Sciences, Mashhad, Iran
  125. 125. Kermanshah University of Medical Sciences, Kermanshah, Iran
  126. 126. Psychiatric Clinics of the University of Basel, Basel Switzerland
  127. 127. Tehran University of Medical Sciences, Tehran, Iran
  128. 128. Pontificia Universidad Catolica de Chile, Santiago, Chile
  129. 129. University of Kragujevac, Kragujevac, Serbia
  130. 130. University of Antioquia, Medellin, Colombia
  131. 131. Nous Therapy Center, Thessaloniki, Greece
  132. 132. Jubilee Mission Medical College & Research Institute, Thrissur, India
  133. 133. Pushpagiri Institute of Medical Sciences, Thiruvalla, Kerala, India
  134. 134. Pakistan Psychiatric Research Centre-Fountain House, Lahore, Pakistan
  135. 135. Faculty of Psychiatry, College of Physicians and Surgeons, Jinnah Postgraduate Medical Centre, and Jinnah Sindh Medical University in Karachi, Pakistan
  136. 136. Tees Esk & Wear Valleys NHS Foundation Trust, United Kingdom
  137. 137. Irrua Specialist Teaching Hospital, Edo State, Nigeria
  138. 138. UC San Diego, CA, United States
  139. 139. University of British Columbia, Vancouver, Canada
  140. 140. Alberta Health Services and the University of Calgary, Calgary, Canada
  141. 141. Ain Shams University, Cairo, Egypt
  142. 142. Ora University, Oran, Algeria
  143. 143. University of Eastern Finland, Kuopio, Finland
  144. 144. Yonsei University College of Medicine, Seoul, South Korea
  145. 145. Wonju College of Medicine, Wonju, South Korea
  146. 146. University of Monastir, Monastir, Tunisia
  147. 147. Republican Scientific and Practical Center of Mental Health, Almaty, Kazakhstan
  148. 148. Gaza Community Mental Health Programme, Gaza, Palestine
  149. 149. Sheba Medical Center, Israel

Source: Journal of the American Academy of Child and Adolescent Psychiatry Published:2025


Abstract

Objective: To identify the COVID-19 pandemic impact on well-being/mental health, coping strategies, and risk factors in adolescents worldwide. Method: This study was based on an anonymous online multi-national/multi-language survey in the general population (representative/weighted non-representative samples, 14-17 years of age), measuring change in well-being (World Health Organization–Five Well-Being Index [WHO-5]/range = 0-100) and psychopathology (validated composite P-score/range = 0-100), WHO-5 <50 and <29, pre- vs during COVID-19 pandemic (April 26, 2020-June 26, 2022). Coping strategies and 9 a priori– defined individual/cumulative risk factors were measured. A χ2, penalized cubic splines, linear regression, and correlation analyses were conducted. Results: Analyzing 8,115 of 8,762 initiated surveys (representative = 75.1%), the pre-pandemic WHO-5 and P-score remained stable during the study (excluding relevant recall bias/drift), but worsened during the pandemic by 5.55 ± 17.13 (SD) and 6.74 ± 16.06 points, respectively (effect size d = 0.27 and d = 0.28). The proportion of adolescents with WHO-5 scores suggesting depression screening (<50) and major depression (<29) increased from 9% to 17% and 2% to 6%. WHO-5 worsened (descending magnitude, with cumulative effect) in adolescents with a mental or physical disorder, female gender, and with school closure. Results were similar for the P-score, with the exception of school closure (not significant) and living in a low-income country, as well as not living in a large city (significant). Changes were significantly but minimally related to COVID-19 deaths/restrictions, returning to near–pre-pandemic values after >2 years. The 3 most subjectively effective coping strategies were Internet use, exercise/walking, and social contacts. Conclusion: Overall, well-being/mental health worsened (small effect sizes) during the early stages of the COVID-19 pandemic, especially in vulnerable subpopulations. Identified at-risk groups, association with pandemic-related measures, and coping strategies can inform individual behaviors and global public health strategies. Plain language summary: The impact of COVID-19 and related restrictions on the mental health of children and adolescents remains unclear. This study conducted an anonymous online survey with over 8,100 adolescents aged 14 to 17 years worldwide. Results showed a significant decline in wellbeing, with depression rates increasing from 9% to 17% returning to near- pre-pandemic values after about 2 years. Adolescents with preexisting mental health conditions, female youth, and those affected by school closures were particularly vulnerable. Effective coping strategies included internet use, exercise, and social contacts, highlighting areas for public health focus to support youth during pandemics. Study preregistration information: Physical and mental health impact of COVID-19 on children, adolescents, and their families: The Collaborative Outcomes study on Health and Functioning during Infection Times - Children and Adolescents (COH-FIT-C&A); https://doi.org/10.1016/j.jad.2021.09.090 Diversity & Inclusion Statement: We worked to ensure sex and gender balance in the recruitment of human participants. We worked to ensure race, ethnic, and/or other types of diversity in the recruitment of human participants. We worked to ensure that the study questionnaires were prepared in an inclusive way. The author list of this paper includes contributors from the location and/or community where the research was conducted who participated in the data collection, design, analysis, and/or interpretation of the work. We actively worked to promote inclusion of historically underrepresented racial and/or ethnic groups in science in our author group. We actively worked to promote sex and gender balance in our author group. One or more of the authors of this paper self-identifies as a member of one or more historically underrepresented racial and/or ethnic groups in science. © 2024 American Academy of Child and Adolescent Psychiatry
Experts (# of related papers)
Other Related Docs
17. Tools for Assessing Mental Health Conditions at Work: A Scoping Review, Journal of Health and Safety at Work (2025)