Efficient Copper-Catalyzed Synthesis of 2-Arylbenzimidazole Derivatives by Reaction of 1-Fluoro-2-Nitrobenzene With Benzamidine Hydrochlorides

Efficient Copper-Catalyzed Synthesis of 2-Arylbenzimidazole Derivatives by Reaction of 1-Fluoro-2-Nitrobenzene With Benzamidine Hydrochlorides Publisher

Sayahi MH¹ ; Khoshneviszadeh M² ; Soheilizad M³ ; Saghanezhad SJ⁴ ; Mahdavi M⁵

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1. Department of Chemistry, Payame Noor University (PNU), P.O. Box 19395-3697, Tehran, Iran
2. Medicinal & Natural Products Chemistry Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
3. CinnaGen Medical Biotechnology Research Center, Alborz University of Medical Sciences, Karaj, Iran
4. ACECR-Production Technology Research Institute, Ahvaz, Iran
5. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism, Clinical Sciences Institute Tehran University of Medical Sciences, Tehran, Iran

Source: Chemistry of Heterocyclic Compounds Published:2018

Abstract

[Figure not available: see fulltext.] A novel and efficient approach to the preparation of 2-arylbenzimidazoles is described. Heating a mixture of 1-fluoro-2-nitrobenzene and benzamidine hydrochlorides in the presence of CuBr and K2CO3 in DMSO afforded 2-arylbenzimidazoles in good to excellent yields. The reaction was initiated by nucleophilic aromatic substitution and further proceeded by intramolecular nucleophilic copper-catalyzed cyclization reaction of benzamidine. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Style	Citing Format
MLA	Sayahi MH, et al.. "Efficient Copper-Catalyzed Synthesis of 2-Arylbenzimidazole Derivatives by Reaction of 1-Fluoro-2-Nitrobenzene With Benzamidine Hydrochlorides." Chemistry of Heterocyclic Compounds, vol. 54, no. 3, 2018, pp. 351-354.
APA	Sayahi MH, Khoshneviszadeh M, Soheilizad M, Saghanezhad SJ, Mahdavi M (2018). Efficient Copper-Catalyzed Synthesis of 2-Arylbenzimidazole Derivatives by Reaction of 1-Fluoro-2-Nitrobenzene With Benzamidine Hydrochlorides. Chemistry of Heterocyclic Compounds, 54(3), 351-354.
Chicago	Sayahi MH, Khoshneviszadeh M, Soheilizad M, Saghanezhad SJ, Mahdavi M. "Efficient Copper-Catalyzed Synthesis of 2-Arylbenzimidazole Derivatives by Reaction of 1-Fluoro-2-Nitrobenzene With Benzamidine Hydrochlorides." Chemistry of Heterocyclic Compounds 54, no. 3 (2018): 351-354.
Harvard	Sayahi MH et al. (2018) 'Efficient Copper-Catalyzed Synthesis of 2-Arylbenzimidazole Derivatives by Reaction of 1-Fluoro-2-Nitrobenzene With Benzamidine Hydrochlorides', Chemistry of Heterocyclic Compounds, 54(3), pp. 351-354.
Vancouver	Sayahi MH, Khoshneviszadeh M, Soheilizad M, Saghanezhad SJ, Mahdavi M. Efficient Copper-Catalyzed Synthesis of 2-Arylbenzimidazole Derivatives by Reaction of 1-Fluoro-2-Nitrobenzene With Benzamidine Hydrochlorides. Chemistry of Heterocyclic Compounds. 2018;54(3):351-354.
BibTex	@article{ author = {Sayahi MH and Khoshneviszadeh M and Soheilizad M and Saghanezhad SJ and Mahdavi M}, title = {Efficient Copper-Catalyzed Synthesis of 2-Arylbenzimidazole Derivatives by Reaction of 1-Fluoro-2-Nitrobenzene With Benzamidine Hydrochlorides}, journal = {Chemistry of Heterocyclic Compounds}, volume = {54}, number = {3}, pages = {351-354}, year = {2018} }
RIS	TY - JOUR AU - Sayahi MH AU - Khoshneviszadeh M AU - Soheilizad M AU - Saghanezhad SJ AU - Mahdavi M TI - Efficient Copper-Catalyzed Synthesis of 2-Arylbenzimidazole Derivatives by Reaction of 1-Fluoro-2-Nitrobenzene With Benzamidine Hydrochlorides JO - Chemistry of Heterocyclic Compounds VL - 54 IS - 3 SP - 351 EP - 354 PY - 2018 ER -

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