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Evaluation of Correlation Between Diopsys® Nova™ Fixed-Luminance Flicker Erg and Diagnosys® Espion 2™ Flicker Erg Parameters Publisher Pubmed



Regenold J1, 2 ; Doan HL1, 3 ; Ghoraba H1 ; Khojasteh H1, 4 ; Jaclyn Hwang JJ1 ; Yavari N1 ; Akhavanrezayat A1 ; Than NTT1 ; Le AHD1, 5 ; Halim MS1, 6 ; Nguyen QD1
Authors
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Authors Affiliations
  1. 1. Spencer Center for Vision Research, Byers Eye Institute, Stanford University School of Medicine, 2452 Watson Court, Suite 200, Palo Alto, 94303, CA, United States
  2. 2. University of Cincinnati College of Medicine, Cincinnati, OH, United States
  3. 3. Pham Ngoc Thach University of Medicine, Saigon, Viet Nam
  4. 4. Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. University of Missouri – Kansas City School of Medicine, Kansas City, MO, United States
  6. 6. Ocular Imaging Research and Reading Center, Sunnyvale, CA, United States

Source: Documenta Ophthalmologica Published:2023


Abstract

Purpose: Diopsys® NOVA™ is a novel full-field electroretinography (ffERG) device that can make rapid measurements of retinal electrophysiologic function. Diagnosys® Espion 2™ is a clinical gold-standard ERG device. This study aimed to investigate whether light-adapted Diopsys® NOVA™ fixed-luminance flicker ffERG magnitude and implicit time (converted from phase) measurements correlate with light-adapted Diagnosys® Espion 2™ flicker ffERG amplitude and implicit time measurements, respectively. Methods: Twelve patients (22 eyes) with various retinal and uveitic diseases underwent light-adapted Diagnosys® Espion 2™ and Diopsys® NOVA™ fixed-luminance flicker testing. Diopsys® magnitude and implicit time (converted from phase) measurements were compared to Diagnosys® amplitude and implicit time measurements, and a Pearson correlation was used to evaluate any existing correlation. Groups were also compared using generalized estimating equations. Bland–Altman plots were utilized to determine agreement between the comparison groups. Results: Age of patients ranged from 14 to 87 years. 58% (n = 7/12) of patients were female. A significant, positive correlation (r = 0.880, P < 0.001) was observed between magnitude (Diopsys®) and amplitude (Diagnosys®) measurements. Amplitude increases by 6.69 µV for each 1 µV increase in Magnitude (p-value < 0.001). A statistically significant, strong positive correlation was observed between Diopsys® implicit time measurements (converted from phase) and Diagnosys® implicit time measurements (r = 0.814, p-value < 0.001). For each 1 ms increase in Diopsys® implicit time, Diagnosys® implicit time increases by 1.13 ms (p-value < 0.001). Conclusions: There is a statistically significant positive correlation between light-adapted Diopsys® NOVA™ fixed-luminance flicker amplitude and Diagnosys® flicker magnitude values. Additionally, there is a statistically significant positive correlation between Diopsys® NOVA™ fixed-luminance flicker implicit time (converted from phase) and Diagnosys® flicker implicit time values. These results imply that the Diopsys® NOVA™ module, which utilizes the nonstandard shortened International Society for Clinical Electrophysiology of Vision (ISCEV) ERG protocol, can produce reliable light-adapted flicker ffERG measurements. © 2023, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.