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Antigen-Independent Killer Cells Prepared for Adoptive Immunotherapy: One Source, Divergent Protocols, Diverse Nomenclature Publisher Pubmed



Torabirahvar M1 ; Aghayan HR2 ; Ahmadbeigi N3
Authors
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Authors Affiliations
  1. 1. SABZ Biomedicals Science-Based Company, Tehran, Iran
  2. 2. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Cell-Based Therapies Research Center, Digestive Disease Research Institute, Shariati Hospital, Tehran University of Medical Sciences, North Kargar Ave, Tehran, 14117, Iran

Source: Journal of Immunological Methods Published:2020


Abstract

Adoptive cell therapy (ACT) using tumor antigen-independent killer cells has been widely used in clinical trials of cancer treatment. Circumventing the need for identification of a particular tumor-associated antigen on tumor cells, the approach has opened possibilities for the extension of ACT immunotherapy to patients with a wide variety of cancer types. Namely, Natural Killer (NK), Lymphokine-activated Killer (LAK) cells and Cytokine-induced killer (CIK) cells are the most commonly used cell types in antigen-independent adoptive immunotherapy of cancer. They all originate from peripheral blood mononuclear cells and share several common features in their killing mechanisms. However, despite broad application in clinical settings, the boundaries between these cell types are not very clearly defined. The current study aims to review different aspects of these cell populations in terms of phenotypical characteristic and preparation media, to clarify how the boundaries are set. © 2019
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