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Neuroprotective Properties of Photobiomodulation in Retinal Regeneration in Rats: Perspectives From Interaction Levels Publisher



Mansouri V1 ; Razzaghi M2 ; Rostaminejad M3 ; Rezaeitavirani M4 ; Heidari MH1 ; Safari S5 ; Arjmand B6 ; Rezaeitavirani M4 ; Zali A7 ; Hamdieh M8
Authors
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Authors Affiliations
  1. 1. Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. Laser Application in Medical Sciences Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Firoozabadi Hospital, Faculty of Medicine, Iran University of Medical Sciences, Tehran, Iran
  5. 5. Proteomics Research Center, Department of Emergency Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  6. 6. Cell Therapy and Regenerative Medicine Research Center, Endocrinology and Metabolism Molecular-Cellular Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Functional Neurosurgery Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  8. 8. Department of Psychosomatic, Taleghani Hospital, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Journal of Lasers in Medical Sciences Published:2020


Abstract

Introduction: Photobiomodulation (PBM) is known as low-level laser (or light) therapy and is applied in different fields of medicine. However, it is required that its molecular and cellular mechanism be investigated. This study aims to assess the neuroprotective properties of PBM in the rat retina. Methods: GSE22818 was downloaded from Gene Expression Omnibus (GEO) and the regulation of the significant differentially expressed genes (DEGs) which are produced by light damage in the rat retina by the pretreatment of PBM application was assessed via network analysis and gene ontology enrichment. Results: The 78 produced DEGs by light-damage in the rat retina were protected via PBM pretreatment action. Among these determined DEGs, 53 individuals were included in the main connected component of the constructed protein-protein interaction (PPI) network. Ccl2, Icam1, Cxcl10, Timp1, and Fos were determined as hub nodes. Eight clusters including 26 regulated biochemical pathways by PBM pretreatment were identified. The critical DEGs based on the action maps were introduced. Conclusion: The finding indicates that PBM treatment protects rat retina against light damage via the prevention of Fos, Ccl2, Icam1, Cxcl10, and Myc dysregulation. © 2020, Laser Application in Medical Sciences Research Center.
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