Respiratory Bacterial and Fungal Superinfections During the Third Surge of the Covid-19 Pandemic in Iran

Respiratory Bacterial and Fungal Superinfections During the Third Surge of the Covid-19 Pandemic in Iran Publisher Pubmed

Mobarak Qamsari M¹ ; Sahebi L² ; Salehi MR³ ; Labbanimotlagh Z⁴ ; Shavandi M⁴ ; Alijani N⁵ ; Amini S⁶ ; Sefidbakht S⁷ ; Feizabadi MM^{1, 8}

Show Affiliations

1. Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, 1417613151, Iran
2. Family Health Research Institute, Maternal Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran
3. Research Center for Antibiotic Stewardship and Antimicrobial Resistance, Infectious Diseases Department, Imam Khomeini Hospital Complex, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
5. Department of Infectious Disease, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
6. Department of Pulmonary and Critical Care, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
7. Department of Pathology, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran
8. Thoracic Research Center, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Microbial Drug Resistance Published:2023

Abstract

Objective: We characterized bacterial and fungal superinfection and evaluated the antimicrobial resistance profile against the most common superinfection-causing pathogens (Klebsiella pneumoniae, Acinetobacter baumannii, and Staphylococcus aureus). Methods: In a cross-sectional study, 192 respiratory samples were collected from patients with and without SARS-COV-2 admitted to a teaching hospital in Tehran. Superinfection proportions and the antibiotic resistance profile were assessed and compared with demographic, comorbidities, and other clinical factors. Results: Superinfection rate was 60% among COVID-19 patients (p = 0.629). Intensive care unit admission (p = 0.017), mortality rate (p ≤ 0.001), and antiviral and corticosteroid therapy (p ≤ 0.001) were significantly more common among patients with severe acute respiratory syndrome coronavirus 2 (SARS-COV-2). The most common superinfections were caused by K. pneumoniae (42.7%, 82/192), A. baumannii (14.6%, 28/192), and S. aureus (13%, 25/192). A. baumannii isolates exhibited greater antibiotic resistance. Forty-four percent (11/25) of S. aureus isolates were cefoxitin resistant and also confirmed as methicillin-resistant S. aureus by PCR. Conclusion: The rise of difficult-to-treat infections with a high burden of antibiotic resistance, coupled with an increase in mortality rate of SARS-COV-2 superinfected individuals, illustrates the impact of the COVID-19 pandemic on antimicrobial resistance. Post-pandemic antimicrobial resistance crisis management requires precise microbiological diagnosis, drug susceptibility testing, and prescription of antimicrobials appropriate for the patient's condition. © 2023 Mary Ann Liebert, Inc., publishers.

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Mohammad Mehdi Feizabadi (1)

Mohammadreza Salehi (1)

Style	Citing Format
MLA	Mobarak Qamsari M, et al.. "Respiratory Bacterial and Fungal Superinfections During the Third Surge of the Covid-19 Pandemic in Iran." Microbial Drug Resistance, vol. 29, no. 3, 2023, pp. 104-111.
APA	Mobarak Qamsari M, Sahebi L, Salehi MR, Labbanimotlagh Z, Shavandi M, Alijani N, Amini S, Sefidbakht S, Feizabadi MM (2023). Respiratory Bacterial and Fungal Superinfections During the Third Surge of the Covid-19 Pandemic in Iran. Microbial Drug Resistance, 29(3), 104-111.
Chicago	Mobarak Qamsari M, Sahebi L, Salehi MR, Labbanimotlagh Z, Shavandi M, Alijani N, Amini S, Sefidbakht S, Feizabadi MM. "Respiratory Bacterial and Fungal Superinfections During the Third Surge of the Covid-19 Pandemic in Iran." Microbial Drug Resistance 29, no. 3 (2023): 104-111.
Harvard	Mobarak Qamsari M et al. (2023) 'Respiratory Bacterial and Fungal Superinfections During the Third Surge of the Covid-19 Pandemic in Iran', Microbial Drug Resistance, 29(3), pp. 104-111.
Vancouver	Mobarak Qamsari M, Sahebi L, Salehi MR, Labbanimotlagh Z, Shavandi M, Alijani N, et al.. Respiratory Bacterial and Fungal Superinfections During the Third Surge of the Covid-19 Pandemic in Iran. Microbial Drug Resistance. 2023;29(3):104-111.
BibTex	@article{ author = {Mobarak Qamsari M and Sahebi L and Salehi MR and Labbanimotlagh Z and Shavandi M and Alijani N and Amini S and Sefidbakht S and Feizabadi MM}, title = {Respiratory Bacterial and Fungal Superinfections During the Third Surge of the Covid-19 Pandemic in Iran}, journal = {Microbial Drug Resistance}, volume = {29}, number = {3}, pages = {104-111}, year = {2023} }
RIS	TY - JOUR AU - Mobarak Qamsari M AU - Sahebi L AU - Salehi MR AU - Labbanimotlagh Z AU - Shavandi M AU - Alijani N AU - Amini S AU - Sefidbakht S AU - Feizabadi MM TI - Respiratory Bacterial and Fungal Superinfections During the Third Surge of the Covid-19 Pandemic in Iran JO - Microbial Drug Resistance VL - 29 IS - 3 SP - 104 EP - 111 PY - 2023 ER -

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