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Voltammetric Detection of Clopidogrel in Pharmaceuticals Utilizing Electropolymerized O-Aminophenol-Mwcnts Modified Electrode Publisher



Barin SM3 ; Mohammadi A3, 4 ; Naeemy A3 ; Darbasizadeh B5
Authors
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Authors Affiliations
  1. 1. Department of Pharmaceutical Nanotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Food and Drug Laboratory Research Center, Food and Drug Organization, Tehran, Iran
  3. 3. Department of Drug and Food Control, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Pharmaceutical Quality Assurance Research Center, The Institute of Pharmaceutical Sciences (TIPS), Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Pharmaceutics and Pharmaceutical Nanotechnology, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Russian Journal of Electrochemistry Published:2023


Abstract

Abstract: In the present study, Clopidogrel (CLP), an anti-platelet drug, was analyzed utilizing electropolymerized o-aminophenol (EpoAP) and multi-walled carbon nanotubes (MWCNTs) modified graphite electrode (GE). The prepared electrode was characterized by Cyclic Voltammetry (CV) and Scanning Electron Microscopy (SEM) techniques. The dependence of peak intensities on pH, scan rate, and MWCNTs amount were further investigated. Electrochemical determination of CLP was evaluated by Differential Pulse Voltammetry (DPV) and CV analysis under optimized working conditions. The calibration curves of CLP obtained in the range of 2.0–75.0 µM by DPV and 50.0–200.0 µM by CV. The limits of detection (LOD) calculated to be 0.50 and 6.6 µM via DPV and CV, respectively. In addition, surface area and coverage of the modified electrode, electron-transfer coefficient, and the diffusion coefficient of CLP were calculated. Finally, the fabricated electrode was proved successfully for quantification of CLP in pharmaceuticals directly, which means it’s not necessary to separate the excipients of the tablets for the analysis, with a mean recovery of 97.49%. © 2023, Pleiades Publishing, Ltd.
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