Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Probiotics Supplementation for the Obesity Management; a Systematic Review of Animal Studies and Clinical Trials Publisher



Ejtahed HS1 ; Angoorani P1 ; Soroush AR1 ; Atlasi R2 ; Hasaniranjbar S1 ; Mortazavian AM3 ; Larijani B4
Authors
Show Affiliations
Authors Affiliations
  1. 1. Obesity and Eating Habits Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Evidence Based Practice Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Food Science and Technology, Faculty of Nutrition Sciences and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  4. 4. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Journal of Functional Foods Published:2019


Abstract

Obesity has been declared as global epidemic that has nearly doubled during recent decades. In this systematic review, PubMed, Web of Science, EMBASE, Cochrane and Scopus databases were searched for entire animal studies and clinical trials focusing on the effects of various probiotic supplements on obesity up to September 2018. Of 3405 studies identified through searching literatures, finally 72 experimental studies and 15 clinical trials were included. Among the animal studies, probiotic supplementation led to reduced weight gain or fat accumulation in 61 studies using different strains of Lactobacillus and Bifidobacterium. Five of clinical trials were conducted on obese children and adolescents. Three of them revealed positive results, one of them showed no effect and the other one caused weight gain. Among the other ten clinical trials conducted on obese adults, nine studies showed probiotic efficiency in reducing weight or waist circumferences. Specific strains of probiotics had anti-obesity effects. © 2018
Related Docs
View other Related Docs
1. Gut Microbiota As a Target in the Pathogenesis of Metabolic Disorders: A New Approach to Novel Therapeutic Agents, Hormone and Metabolic Research (2016)
2. Probiotic Supplementation and High‐Intensity Interval Training Modify Anxiety‐Like Behaviors and Corticosterone in High‐Fat Diet‐Induced Obesity Mice, Nutrients (2021)
3. Targeting Obesity Management Through Gut Microbiota Modulation by Herbal Products: A Systematic Review, Complementary Therapies in Medicine (2019)
4. Probiotics As Beneficial Agents in the Management of Diabetes Mellitus: A Systematic Review, Diabetes/Metabolism Research and Reviews (2016)
5. Diabetes Management by Probiotics: Current Knowledge and Future Perspectives, International Journal for Vitamin and Nutrition Research (2016)
6. Effect of Probiotic and Synbiotic Supplementation on Inflammatory Markers in Health and Disease Status: A Systematic Review and Meta-Analysis of Clinical Trials, Clinical Nutrition (2020)
7. Gut Microbiota: A Perspective of Precision Medicine in Endocrine Disorders, Journal of Diabetes and Metabolic Disorders (2020)
8. Gut Microbiota-Derived Metabolites in Obesity: A Systematic Review, Bioscience of Microbiota# Food and Health (2020)
Experts (# of related papers)
View all Related Experts
Hanieh-Sadat Ejtahed (33)
Shirin Hasani-Ranjbar (23)
Other Related Docs
9. Efficacy of Probiotics in Overweight and Obesity Control: An Umbrella Review and Subgroup Meta-Analysis, Probiotics and Antimicrobial Proteins (2024)
10. Gut Microbiota Modulation As a Possible Mediating Mechanism for Fasting-Induced Alleviation of Metabolic Complications: A Systematic Review, Nutrition and Metabolism (2021)
11. The Anti-Obesity Effects of Postbiotics: A Systematic Review of Pre-Clinical and Clinical Studies, Clinical Nutrition ESPEN (2024)
12. Multidimensional Perspective of Obesity; Prevention to Treatment, Journal of Diabetes and Metabolic Disorders (2021)
13. Microbiota Research in Iran; Current Knowledge and Future Perspective, Journal of Diabetes and Metabolic Disorders (2021)
14. The Effects of Prebiotic, Probiotic or Synbiotic Supplementation on Overweight/Obesity Indicators: An Umbrella Review of the Trials’ Meta-Analyses, Frontiers in Endocrinology (2024)
15. The Effects of Probiotics, Prebiotics, and Synbiotics on Polycystic Ovarian Syndrome: An Overview of Systematic Reviews, Frontiers in Medicine (2023)
16. The Role of Probiotics in Management of Infected Diabetic Foot Ulcers, Journal of Mazandaran University of Medical Sciences (2021)
17. Adaptation of Human Gut Microbiota to Bariatric Surgeries in Morbidly Obese Patients: A Systematic Review, Microbial Pathogenesis (2018)
18. Role of Gut Microbiota on Weight Regulation, Govaresh (2018)
19. Comparison of the Effect of Daily Consumption of Probiotic Compared With Low-Fat Conventional Yogurt on Weight Loss in Healthy Obese Women Following an Energy-Restricted Diet: A Randomized Controlled Trial, American Journal of Clinical Nutrition (2016)
20. The Effect of Probiotic Supplementation on Glycemic Control and Lipid Profile in Patients With Type 2 Diabetes: A Randomized Placebo Controlled Trial, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2019)
21. Main Gut Bacterial Composition Differs Between Patients With Type 1 and Type 2 Diabetes and Non-Diabetic Adults, Journal of Diabetes and Metabolic Disorders (2020)
22. The Future of Diabetes Management by Healthy Probiotic Microorganisms, Current Diabetes Reviews (2017)
23. A Critical Review on Akkermansia Muciniphila: Functional Mechanisms, Technological Challenges, and Safety Issues, Probiotics and Antimicrobial Proteins (2023)
24. Probiotics As a New Regulator for Bone Health: A Systematic Review and Meta-Analysis, Evidence-based Complementary and Alternative Medicine (2021)
25. Investigation of the Probiotic Supplement’S Effect on Obese Adults Demonstrated a Reduction in Fasting Insulin Levels: A Double-Blind Randomized Clinical Trial, Journal of Diabetes and Metabolic Disorders (2024)
26. Non-Alcoholic Fatty Liver Diseases: From Role of Gut Microbiota to Microbial-Based Therapies, European Journal of Clinical Microbiology and Infectious Diseases (2020)
27. Adherence to the Mediterranean Diet Can Beneficially Affect the Gut Microbiota Composition: A Systematic Review, BMC Medical Genomics (2024)
28. Do Probiotics, Prebiotics and Synbiotics Affect Adiponectin and Leptin in Adults? a Systematic Review and Meta-Analysis of Clinical Trials, Clinical Nutrition (2019)
29. Worldwide Trends in Scientific Publications on Association of Gut Microbiota With Obesity, Iranian Journal of Basic Medical Sciences (2019)
30. Neuromodulatory Effect of Microbiome on Gut-Brain Axis; New Target for Obesity Drugs, Journal of Diabetes and Metabolic Disorders (2019)
31. The Effects of Gut Microbiome Manipulation on Glycemic Indices in Patients With Non-Alcoholic Fatty Liver Disease: A Comprehensive Umbrella Review, Nutrition and Diabetes (2024)
32. Gut Microbiota Composition in Obese and Normal Weight Adults in Iran, Journal of Mazandaran University of Medical Sciences (2021)
33. A Systematic Review and Meta-Analysis of the Probiotics and Synbiotics Effects on Oxidative Stress, Journal of Functional Foods (2018)
34. Comparative Efficacy and Safety of Probiotics, Prebiotics, and Synbiotics for Type 2 Diabetes Management: A Systematic Review and Network Meta-Analysis, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2024)
35. The Impact of Probiotic Supplementation on Weight and Body Composition in Older Adults: A Systematic Review, Journal of Biological Regulators and Homeostatic Agents (2024)
36. Metformin Induces Weight Loss Associated With Gut Microbiota Alteration in Non-Diabetic Obese Women: A Randomized Double-Blind Clinical Trial, European Journal of Endocrinology (2019)
37. The Effects of Synbiotic Supplementation on Serum Anti-Inflammatory Factors in the Survivors of Breast Cancer With Lymphedema Following a Low Calorie Diet: A Randomized, Double-Blind, Clinical Trial, Nutrition and Cancer (2022)
38. Modulation of Efferocytosis and Inflammation Resolution by Live and Non-Live Probiotics Through Gut Microbiota Interactions in Preclinical and Clinical Studies, Food Bioscience (2024)
39. The Influence of Probiotics Consumption on Management of Prediabetic State: A Systematic Review of Clinical Trials, International Journal of Clinical Practice (2022)
40. Therapeutic and Nutritional Effects of Synbiotic Yogurts in Children and Adults: A Clinical Review, Probiotics and Antimicrobial Proteins (2020)
41. Our Little Friends With Big Roles: Alterations of the Gut Microbiota in Thyroid Disorders, Endocrine# Metabolic and Immune Disorders - Drug Targets (2020)
42. Is Probiotic and Synbiotic Supplementation Effective on Immune Cells? a Systematic Review and Meta-Analysis of Clinical Trials, Food Reviews International (2021)
43. An Overview on Probiotics As an Alternative Strategy for Prevention and Treatment of Human Diseases, Iranian Journal of Pharmaceutical Research (2019)
44. Bacillus Coagulans T4 and Lactobacillus Paracasei Td3 Ameliorate Skeletal Muscle Oxidative Stress and Inflammation in High-Fat Diet-Fed C57bl/6J Mice, Iranian Journal of Pharmaceutical Research (2023)
45. The Effect of Probiotic and Synbiotic Supplementation on Lipid Parameters Among Patients With Cardiometabolic Risk Factors: A Systematic Review and Meta-Analysis of Clinical Trials, Cardiovascular Research (2023)
46. Effects of Probiotics and Synbiotic Supplementation on Antioxidant Status: A Meta-Analysis of Randomized Clinical Trials, Clinical Nutrition ESPEN (2019)
47. Inspection of Heritable Gut Microbiota Roles in Obesity, Journal of Biological Regulators and Homeostatic Agents (2023)
48. Effect of Multispecies Probiotic Supplements on Serum Minerals, Liver Enzymes and Blood Pressure in Patients With Type 2 Diabetes, International Journal of Diabetes in Developing Countries (2015)
49. The Role of Intestinal Microbiota in Cognitive Disorders, Journal of Mazandaran University of Medical Sciences (2021)
50. Dietary Supplements and Pediatric Non-Alcoholic Fatty Liver Disease: Present and the Future, World Journal of Hepatology (2015)