Microsurgical Anastomosis of Renal Vasculature in Rats: A Practical Platform for Acellular Kidney Transplantation Publisher Pubmed



Kajbafzadeh AM¹ ; Khorramirouz R¹ ; Kameli SM¹ ; Nabavizadeh B¹ Show Affiliations
Source: Journal of Pediatric Urology Published:2018

Abstract

End-stage renal disease is becoming a contemporary global concern with increasing prevalence. The available treatment strategies are limited to dialysis and renal transplantation. However, limited organ supply and autoimmune rejection are the shortcomings that limit widespread application of transplantation. Favorably, regenerative medicine is able to provide acellular natural scaffolds for renal transplantation. Experimental surgeries in animal models are a fundamental step in transplantation research. This video presents a practical method for transplantation of bilateral acellular kidneys in a rat model, which could serve as a key step for further research. © 2018 Journal of Pediatric Urology Company