Improvement of the Van Leusen Reaction in the Presence of Β-Cyclodextrin: A Green and Efficient Synthesis of Oxazoles in Water

Improvement of the Van Leusen Reaction in the Presence of Β-Cyclodextrin: A Green and Efficient Synthesis of Oxazoles in Water Publisher

Rahimzadeh G¹ ; Kianmehr E² ; Mahdavi M¹

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1. School of Chemistry, College of Science, University of Tehran, Tehran, Iran
2. Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences Published:2017

Abstract

An efficient approach for the synthesis of oxazoles through the Van Leusen reaction in the presence of β-cyclodextrin is described. In aqueous medium using β-cyclodextrin as a supramolecular catalyst, tosylmethyl isocyanide was deprotonated by triethylamine and subsequently underwent an addition/cyclization reaction with aldehydes to produce corresponding oxazoles in excellent yields. This protocol improves the Van Leusen reaction with the use of catalytic amounts of base at low temperature in green media.

Style	Citing Format
MLA	Rahimzadeh G, Kianmehr E, Mahdavi M. "Improvement of the Van Leusen Reaction in the Presence of Β-Cyclodextrin: A Green and Efficient Synthesis of Oxazoles in Water." Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, vol. 72, no. 12, 2017, pp. 923-926.
APA	Rahimzadeh G, Kianmehr E, Mahdavi M (2017). Improvement of the Van Leusen Reaction in the Presence of Β-Cyclodextrin: A Green and Efficient Synthesis of Oxazoles in Water. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 72(12), 923-926.
Chicago	Rahimzadeh G, Kianmehr E, Mahdavi M. "Improvement of the Van Leusen Reaction in the Presence of Β-Cyclodextrin: A Green and Efficient Synthesis of Oxazoles in Water." Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences 72, no. 12 (2017): 923-926.
Harvard	Rahimzadeh G, Kianmehr E, Mahdavi M (2017) 'Improvement of the Van Leusen Reaction in the Presence of Β-Cyclodextrin: A Green and Efficient Synthesis of Oxazoles in Water', Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences, 72(12), pp. 923-926.
Vancouver	Rahimzadeh G, Kianmehr E, Mahdavi M. Improvement of the Van Leusen Reaction in the Presence of Β-Cyclodextrin: A Green and Efficient Synthesis of Oxazoles in Water. Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences. 2017;72(12):923-926.
BibTex	@article{ author = {Rahimzadeh G and Kianmehr E and Mahdavi M}, title = {Improvement of the Van Leusen Reaction in the Presence of Β-Cyclodextrin: A Green and Efficient Synthesis of Oxazoles in Water}, journal = {Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences}, volume = {72}, number = {12}, pages = {923-926}, year = {2017} }
RIS	TY - JOUR AU - Rahimzadeh G AU - Kianmehr E AU - Mahdavi M TI - Improvement of the Van Leusen Reaction in the Presence of Β-Cyclodextrin: A Green and Efficient Synthesis of Oxazoles in Water JO - Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences VL - 72 IS - 12 SP - 923 EP - 926 PY - 2017 ER -

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