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Genetic Factors in Determination of Risk of External Apical Root Resorption: A Concise Review Publisher



Behnaz M1 ; Jazaeri M2 ; Aghandeh P3 ; Taheri M4 ; Ghafourifard S5
Authors
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Authors Affiliations
  1. 1. Dental Research Center, Research Institute of Dental Sciences, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  2. 2. School of Dentistry, Hamadan University of Medical Sciences, Hamadan, Iran
  3. 3. School of Dentistry, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Urogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  5. 5. Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Source: Gene Reports Published:2020


Abstract

External apical root resorption (EARR) is a sequel of orthodontic interventions that leads to impairment of configuration of root apex of the teeth. This condition is regarded as a complex situation caused by several unidentified environmental and intrinsic parameters. About two-third of variation in EARR is expected to be explained by genetic factors. Several studies have assessed the role of genetic variants in conferring risk of post-orthodontic EARR. Two kinds of genetic polymorphisms were the focus of most of investigations: single nucleotide polymorphisms (SNPs) within cytokine coding genes and SNPs within genes involved in the bone remodeling. The rs1800587 and rs1143634 in IL-1A and IL-1B genes have been the mostly assessed SNPs in different populations. Yet, the results of investigations in different populations are not consistent. In the current study, we summarize the results of studies which assessed the contribution of genetic factors in EARR. As genetic factors are involved in conferring risk of EARR, evaluation of these variants prior to establishment of orthodontic treatments might help in identification of at-risk individuals and better follow-up of these patients. © 2020 Elsevier Inc.
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