The Effect of T Helper (Th)/T Cytotoxic (Tc) Ratio on Disease Severity in Type a Hemophilia Patients

The Effect of T Helper (Th)/T Cytotoxic (Tc) Ratio on Disease Severity in Type a Hemophilia Patients Publisher Pubmed

Khazaei HA¹ ; Naderi M² ; Aliabad GM³ ; Tabatabaei SMN¹ ; Alidadi A¹ ; Moulaei NA⁴ ; Safdari M¹ ; Nahvi H⁵ ; Cohan N⁶ ; Dehghan J⁷ ; Mehraban A⁸ ; Jalili A⁹ ; Khazaei A¹ ; Khazaei E¹ Show All Authors

Khazaei HA¹
Naderi M²
Aliabad GM³
Tabatabaei SMN¹
Alidadi A¹
Moulaei NA⁴
Safdari M¹
Nahvi H⁵
Cohan N⁶
Dehghan J⁷
Mehraban A⁸
Jalili A⁹
Khazaei A¹
Khazaei E¹
Khazaei B¹
Khazaei B¹
Rezaei N¹⁰
Salarzaie M¹¹
Soleimani G³

Show Affiliations

1. Clinical Immunology Research Center (CIRC), Zahedan University of Medical Sciences, Zahedan, Iran
2. Genetics of Non-Communicable Disease Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
3. Children and Adolescents Health Research Center, Zahedan University of Medical Sciences, Zahedan, Iran
4. Infectious Disease and Tropical Medicine Research Center, Resistance Tuberculosis Institute of Zahedan University of Medical Sciences, Zahedan, Iran
5. Department of Pediatric Surgery, Tehran University of Medical Sciences, Tehran, Iran
6. Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
7. Community Medicine Department, Zahedan University of Medical Sciences, Zahedan, Iran
8. Islamic Azad University, Zahedan Branch, Zahedan, Iran
9. Department of Sport Physiology, Zahedan University of Farhangian, Zahedan, Iran
10. Research Center for Immunodeficiencies, Pediatrics Center of Excellence, Children's Medical Center, Tehran University of Medical Sciences, Tehran, Iran
11. Faculty of Medicine, Zabol University of Medical Sciences, Zabol, Iran

Source: Human Antibodies Published:2021

Abstract

BACKGROUND AND OBJECTIVES: The aim of this study was to investigate the T helper (Th) to T cytotoxic (Tc) ratio in children suffering from type A hemophilia disease and to evaluate the correlation of this ratio with disease severity. MATERIAL AND METHOD: Two mls of EDTA anti coagulated whole blood was collected. Immunophenotyping of lymphocytes count was carried out by FACS analysis using a double CD4 and CD8 kit. The mean ± SD of absolute numbers of CD4 and CD8 lymphocytes/ml was calculated and the ratio of CD4/CD8 was evaluated by statistical method. RESULTS: Among 80 type A hemophilia patients, 66 (82.5%) were male. The mean age was 15 ± 3.51 years. 12 (15%) of them were suffering from mild disease and 68 (85%) had sever disease. The CD4 /CD8 ratio was obtained between 0.45 and 1.44 with mean1.79 ± 0.78. The correlation between this ration and disease severity was 0.019. CONCLUSION: The results showed that CD4/CD8 ratio has correlation with disease severity in type A hemophilia patients, however there was no association between this ratio and gender. © 2021 - IOS Press. All rights reserved.

Style	Citing Format
MLA	Khazaei HA, et al.. "The Effect of T Helper (Th)/T Cytotoxic (Tc) Ratio on Disease Severity in Type a Hemophilia Patients." Human Antibodies, vol. 29, no. 1, 2021, pp. 95-99.
APA	Khazaei HA, Naderi M, Aliabad GM, Tabatabaei SMN, Alidadi A, Moulaei NA, Safdari M, Nahvi H, Cohan N, Dehghan J, Mehraban A, Jalili A, Khazaei A, Khazaei E, Khazaei B, Khazaei B, Rezaei N, Salarzaie M, Soleimani G (2021). The Effect of T Helper (Th)/T Cytotoxic (Tc) Ratio on Disease Severity in Type a Hemophilia Patients. Human Antibodies, 29(1), 95-99.
Chicago	Khazaei HA, Naderi M, Aliabad GM, Tabatabaei SMN, Alidadi A, Moulaei NA, Safdari M, et al.. "The Effect of T Helper (Th)/T Cytotoxic (Tc) Ratio on Disease Severity in Type a Hemophilia Patients." Human Antibodies 29, no. 1 (2021): 95-99.
Harvard	Khazaei HA et al. (2021) 'The Effect of T Helper (Th)/T Cytotoxic (Tc) Ratio on Disease Severity in Type a Hemophilia Patients', Human Antibodies, 29(1), pp. 95-99.
Vancouver	Khazaei HA, Naderi M, Aliabad GM, Tabatabaei SMN, Alidadi A, Moulaei NA, et al.. The Effect of T Helper (Th)/T Cytotoxic (Tc) Ratio on Disease Severity in Type a Hemophilia Patients. Human Antibodies. 2021;29(1):95-99.
BibTex	@article{ author = {Khazaei HA and Naderi M and Aliabad GM and Tabatabaei SMN and Alidadi A and Moulaei NA and Safdari M and Nahvi H and Cohan N and Dehghan J and Mehraban A and Jalili A and Khazaei A and Khazaei E and Khazaei B and Khazaei B and Rezaei N and Salarzaie M and Soleimani G}, title = {The Effect of T Helper (Th)/T Cytotoxic (Tc) Ratio on Disease Severity in Type a Hemophilia Patients}, journal = {Human Antibodies}, volume = {29}, number = {1}, pages = {95-99}, year = {2021} }
RIS	TY - JOUR AU - Khazaei HA AU - Naderi M AU - Aliabad GM AU - Tabatabaei SMN AU - Alidadi A AU - Moulaei NA AU - Safdari M AU - Nahvi H AU - Cohan N AU - Dehghan J AU - Mehraban A AU - Jalili A AU - Khazaei A AU - Khazaei E AU - Khazaei B AU - Khazaei B AU - Rezaei N AU - Salarzaie M AU - Soleimani G TI - The Effect of T Helper (Th)/T Cytotoxic (Tc) Ratio on Disease Severity in Type a Hemophilia Patients JO - Human Antibodies VL - 29 IS - 1 SP - 95 EP - 99 PY - 2021 ER -

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