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The Prevalence and Odds of Bipolar Disorder in Women With Polycystic Ovary Syndrome (Pco) Disease: A Systematic Review and Meta-Analysis Publisher



Shahraki Z1 ; Rastkar M2 ; Ramezanpour MR3 ; Ghajarzadeh M4
Authors
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Authors Affiliations
  1. 1. Zabol Medical Plants Research Center, Zabol University of Medical Sciences, Zabol, Iran
  2. 2. Students Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Faculty of Medicine, Tehran University of Medical Science, Tehran, Iran
  4. 4. Universal Council of Epidemiology (UCE), Universal Scientific Education and Research Network (USERN), Tehran University of Medical Sciences, Tehran, Iran

Source: Archives of Women's Mental Health Published:2024


Abstract

Background: Women with polycystic ovary syndrome (PCO) suffer from psychological difficulties like bipolar disorder. Various studies in the literature report several prevalence rates of bipolar disorder in women with PCO, while there is no systematic review in this field. So, we designed this systematic review and meta-analysis to estimate the pooled prevalence and odds of bipolar disorder in women with PCO disease. Method: PubMed, Scopus, EMBASE, Web of Science, Google Scholar, and references of the references, conference abstracts were comprehensively searched by two independent researchers. The search was done on May 1st, 2023. Results: A literature search revealed 438 records, 35 full texts were evaluated, and finally, 11 studies remained for systematic review. Totally, 73,102 women with PCO and 340,724 controls were evaluated. Among cases, 1471 had bipolar diagnosis vs. 4321 controls. The prevalence of bipolar disorder in women with PCO ranged between 0 and 27%, and the pooled prevalence was estimated as 4% (95% CI, 2–5%; I 2, 99.3%, p < 0.001). The odds of bipolar disorder in women with PCO ranged between 0.98 and 8.78, and the pooled estimate was 2.06 (95% CI, 1.61–2.63) (I 2, 85.6%; p < 0.001). Conclusions: This systematic review and meta-analysis show that the pooled prevalence of bipolar disorder in women with PCO is 4%, and women with PCO are at a 2-fold higher risk of bipolar disorder. © 2024, The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, part of Springer Nature.
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