A Two-Week, Double-Blind, Placebo-Controlled Trial of Viola Odorata, Echium Amoenum and Physalis Alkekengi Mixture in Symptomatic Benign Prostate Hyperplasia (Bph) Men

A Two-Week, Double-Blind, Placebo-Controlled Trial of Viola Odorata, Echium Amoenum and Physalis Alkekengi Mixture in Symptomatic Benign Prostate Hyperplasia (Bph) Men Publisher

Beiraghdar F¹ ; Einollahi B¹ ; Ghadyani A¹ ; Panahi Y¹ ; Hadjiakhoondi A² ; Vazirian M² ; Salarytabar A³ ; Darvishi B⁴

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1. Nephrology and Urology Research Center, Baghiatallah University of Medical Sciences, Tehran, Iran
2. Department of Pharmacognosy and Medical Plants Research Center Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
3. Integrative Oncology Department, Breast Cancer Research Center ACECR, Iran
4. Recombinant Proteins Department, Breast Cancer Research Center ACECR, Tehran, Iran

Source: Pharmaceutical Biology Published:2017

Abstract

Context: As an alternative approach, administration of phytotherapeutic agents in management of benign prostate hyperplasia (BPH), is rapidly growing each day. Different authors have indicated effectiveness of Viola odorata L. (Violaceae), Echium amoenum Fisch. & C.A.Mey. (Boraginaceae) and Physalis alkekengi L. (Solanaceae) in treatment of BPH. However, none have reported the beneficial outcomes of the mixture yet. Objective: This study evaluates the therapeutical effects of V. odorata, E. amoenum and P. alkekengi mixture on symptomatic BPH patients. Materials and methods: Eighty six symptomatic BPH patients with International Prostate Symptom Score (IPSS) of more than 13 and prostate volume of more than 30 cm3 were randomly allocated to receive a two-week course of placebo (control group) or 1 mL of mixed hydro-alcoholic solution of P. alkekengi, E. amoenum and V. odorata extracts (1.5, 1 and 1.5% respectively) (treatment group). Results: IPSS score of incomplete urination (42.3 ± 2.04%), frequency of urination (20.08 ± 1.02%), intermit-tency (40.78 ± 2.16%), urgency (60.91 ± 3.14%), weak stream (50.58 ± 2.14%), straining (55.67 ± 2.53%) and nocturia (40.14 ± 1.89%) in treatment group were significantly decreased after treatment compare to placebo receiving group. Furthermore, the prostate volume (16.92 ± 0.89%) and extant urine volume (28.12 ± 1.36%) also significantly decreased in treatment group compared to control group. No significant side effects or abnormalities in biochemical tests and urinalysis were observed throughout the study. Discussion and conclusions: Based on results, mentioned mixture is safe and effective in improving life quality of patients suffering from BPH. © 2017 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

2. Effectiveness of Echium Amoenum on Premenstrual Syndrome: A Randomized, Double-Blind, Controlled Trial, BMC Complementary Medicine and Therapies (2020)

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Style	Citing Format
MLA	Beiraghdar F, et al.. "A Two-Week, Double-Blind, Placebo-Controlled Trial of Viola Odorata, Echium Amoenum and Physalis Alkekengi Mixture in Symptomatic Benign Prostate Hyperplasia (Bph) Men." Pharmaceutical Biology, vol. 55, no. 1, 2017, pp. 1787-1791.
APA	Beiraghdar F, Einollahi B, Ghadyani A, Panahi Y, Hadjiakhoondi A, Vazirian M, Salarytabar A, Darvishi B (2017). A Two-Week, Double-Blind, Placebo-Controlled Trial of Viola Odorata, Echium Amoenum and Physalis Alkekengi Mixture in Symptomatic Benign Prostate Hyperplasia (Bph) Men. Pharmaceutical Biology, 55(1), 1787-1791.
Chicago	Beiraghdar F, Einollahi B, Ghadyani A, Panahi Y, Hadjiakhoondi A, Vazirian M, Salarytabar A, Darvishi B. "A Two-Week, Double-Blind, Placebo-Controlled Trial of Viola Odorata, Echium Amoenum and Physalis Alkekengi Mixture in Symptomatic Benign Prostate Hyperplasia (Bph) Men." Pharmaceutical Biology 55, no. 1 (2017): 1787-1791.
Harvard	Beiraghdar F et al. (2017) 'A Two-Week, Double-Blind, Placebo-Controlled Trial of Viola Odorata, Echium Amoenum and Physalis Alkekengi Mixture in Symptomatic Benign Prostate Hyperplasia (Bph) Men', Pharmaceutical Biology, 55(1), pp. 1787-1791.
Vancouver	Beiraghdar F, Einollahi B, Ghadyani A, Panahi Y, Hadjiakhoondi A, Vazirian M, et al.. A Two-Week, Double-Blind, Placebo-Controlled Trial of Viola Odorata, Echium Amoenum and Physalis Alkekengi Mixture in Symptomatic Benign Prostate Hyperplasia (Bph) Men. Pharmaceutical Biology. 2017;55(1):1787-1791.
BibTex	@article{ author = {Beiraghdar F and Einollahi B and Ghadyani A and Panahi Y and Hadjiakhoondi A and Vazirian M and Salarytabar A and Darvishi B}, title = {A Two-Week, Double-Blind, Placebo-Controlled Trial of Viola Odorata, Echium Amoenum and Physalis Alkekengi Mixture in Symptomatic Benign Prostate Hyperplasia (Bph) Men}, journal = {Pharmaceutical Biology}, volume = {55}, number = {1}, pages = {1787-1791}, year = {2017} }
RIS	TY - JOUR AU - Beiraghdar F AU - Einollahi B AU - Ghadyani A AU - Panahi Y AU - Hadjiakhoondi A AU - Vazirian M AU - Salarytabar A AU - Darvishi B TI - A Two-Week, Double-Blind, Placebo-Controlled Trial of Viola Odorata, Echium Amoenum and Physalis Alkekengi Mixture in Symptomatic Benign Prostate Hyperplasia (Bph) Men JO - Pharmaceutical Biology VL - 55 IS - 1 SP - 1787 EP - 1791 PY - 2017 ER -

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