Spectrophotometric Determination of Aprepitant in Bulk and Pharmaceutical Dosage Forms Using Bromocresol Green As Chromogenic Reagent

Spectrophotometric Determination of Aprepitant in Bulk and Pharmaceutical Dosage Forms Using Bromocresol Green As Chromogenic Reagent Publisher

Souri E¹ ; Abbasi A¹ ; Amanlou M¹ ; Tehrani MB¹

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1. Department of Medicinal Chemistry, Faculty of Pharmacy and Drug Design and Development Research Center, Tehran University of Medical Sciences, Tehran, 14155-6451, Iran

Source: Asian Journal of Chemistry Published:2018

Abstract

Aprepitant is a substance P/neurokinin 1 receptor antagonist, which is used for preventing both acute and delayed emesis. In the present study a simple and accurate spectrophotometric method has been developed for quantitative determination of aprepitant in bulk and pharmaceutical dosage forms based on the formation of ion-pair complex between the drug and bromocresol green. The 1:1 yellow colour aprepitant-bromocresol green (BCG) ion-pair complex was formed in buffer solution at pH = 4, extracted with chloroform and measured at 413 nm. The optimum reaction conditions such as pH, reagent amount, extracting solvent and stoichiometry of the ion-pair complex were investigated. The developed method showed excellent linearity over the concentration range of 150-500 μg/mL with acceptable correlation coefficient (r2 = 0.998), precision (CV < 3.67 %) and accuracy (Error < 3.46 %). The proposed method was successfully applied for determination of aprepitant in capsule dosage forms and no interference from excipients was observed. © 2018 Chemical Publishing Co. All rights reserved.

Style	Citing Format
MLA	Souri E, et al.. "Spectrophotometric Determination of Aprepitant in Bulk and Pharmaceutical Dosage Forms Using Bromocresol Green As Chromogenic Reagent." Asian Journal of Chemistry, vol. 30, no. 6, 2018, pp. 1331-1334.
APA	Souri E, Abbasi A, Amanlou M, Tehrani MB (2018). Spectrophotometric Determination of Aprepitant in Bulk and Pharmaceutical Dosage Forms Using Bromocresol Green As Chromogenic Reagent. Asian Journal of Chemistry, 30(6), 1331-1334.
Chicago	Souri E, Abbasi A, Amanlou M, Tehrani MB. "Spectrophotometric Determination of Aprepitant in Bulk and Pharmaceutical Dosage Forms Using Bromocresol Green As Chromogenic Reagent." Asian Journal of Chemistry 30, no. 6 (2018): 1331-1334.
Harvard	Souri E et al. (2018) 'Spectrophotometric Determination of Aprepitant in Bulk and Pharmaceutical Dosage Forms Using Bromocresol Green As Chromogenic Reagent', Asian Journal of Chemistry, 30(6), pp. 1331-1334.
Vancouver	Souri E, Abbasi A, Amanlou M, Tehrani MB. Spectrophotometric Determination of Aprepitant in Bulk and Pharmaceutical Dosage Forms Using Bromocresol Green As Chromogenic Reagent. Asian Journal of Chemistry. 2018;30(6):1331-1334.
BibTex	@article{ author = {Souri E and Abbasi A and Amanlou M and Tehrani MB}, title = {Spectrophotometric Determination of Aprepitant in Bulk and Pharmaceutical Dosage Forms Using Bromocresol Green As Chromogenic Reagent}, journal = {Asian Journal of Chemistry}, volume = {30}, number = {6}, pages = {1331-1334}, year = {2018} }
RIS	TY - JOUR AU - Souri E AU - Abbasi A AU - Amanlou M AU - Tehrani MB TI - Spectrophotometric Determination of Aprepitant in Bulk and Pharmaceutical Dosage Forms Using Bromocresol Green As Chromogenic Reagent JO - Asian Journal of Chemistry VL - 30 IS - 6 SP - 1331 EP - 1334 PY - 2018 ER -

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