Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
World Human Neutrophil Antigens Investigation Survey Publisher Pubmed



Bayat B1 ; Lowack J1 ; Audrain M2 ; Croisille L3 ; Curtis B4 ; Dangerfield R5 ; Esmaeili B6, 7 ; Grabowski C8 ; Keller M5 ; Kim H9 ; Kroll H8 ; Kvanka MM10 ; Kwok J11 ; Moritz E12 Show All Authors
Authors
  1. Bayat B1
  2. Lowack J1
  3. Audrain M2
  4. Croisille L3
  5. Curtis B4
  6. Dangerfield R5
  7. Esmaeili B6, 7
  8. Grabowski C8
  9. Keller M5
  10. Kim H9
  11. Kroll H8
  12. Kvanka MM10
  13. Kwok J11
  14. Moritz E12
  15. Nathalang O13
  16. Nelson D14
  17. Nielsen KR15
  18. Pahn G16
  19. Poles A17
  20. Porcelijn L18
  21. Sachs UJ1
  22. Schonbacher M19
  23. Kormoczi GF19
  24. Kupatawintu P20
  25. Takahashi D21
  26. Uhrynowska M22
  27. Flesch B23
  28. Fung YL24
Show Affiliations
Authors Affiliations
  1. 1. Institute for Clinical Immunology, Transfusion Medicine and Haemostasis, Justus-Liebig-University, Gießen, Germany
  2. 2. Service d'Immunologie, Laboratoire de Biologie, Nantes, France
  3. 3. Laboratoire HLA-ILP E.F.S Ile-de-France, Creteil, France
  4. 4. Platelet & Neutrophil Immunology Lab, Versiti, Milwaukee, WI, United States
  5. 5. American Red Cross Neutrophil Immunology Laboratory, St Paul, MN, United States
  6. 6. Department of Basic Medical Sciences, Khoy University of Medical Sciences, Khoy, Iran
  7. 7. Immunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Institut fur Transfusionsmedizin Dessau, DRK-Blutspendedienst NSTOB, Dessau, Germany
  9. 9. Seoul National University Hospital, Seoul, South Korea
  10. 10. Blood Transfusion Centre of Slovenia, Ljubljana, Slovenia
  11. 11. Division of Transplantation and Immunogenetic, Department of Pathology, Queen Mary Hospital, Pok Fu Lam, Hong Kong
  12. 12. Clinical and Experimental Oncology, Escola Paulista de Medicinia, Universidade Federal de Sao Paulo, Sao Paulo, Brazil
  13. 13. Faculty of Allied Health Sciences, Thammasat University, Pathumtani, Thailand
  14. 14. Specialized Laboratory Services, South African National Blood Service, Johannesburg, South Africa
  15. 15. Klinisk Immunologi, Aalborg Universitetshospital Nord, Aalborg, Denmark
  16. 16. Platelet & Granulocyte Reference Laboratory, Australian Red Cross Lifeblood, Brisbane, Australia
  17. 17. Department of Histocompatibility & Immunogenetics, NHS Blood & Transplant, Bristol, United Kingdom
  18. 18. Platelet/Leucocyte Serology Laboratory, Sanquin Diagnostic Services, Amsterdam, Netherlands
  19. 19. Department of Transfusion Medicine and Cell Therapy, Medical University of Vienna, Vienna, Austria
  20. 20. National Blood Centre, Thai Red Cross Society, Bangkok, Thailand
  21. 21. Japanese Red Cross Society Central Blood Institute, Tokyo, Japan
  22. 22. Institute of Hematology and Transfusion Medicine, Warszawa, Poland
  23. 23. Laboratory for Immunogenetics/HLA, DRK Blutspendedienst West, Bad Kreuznach, Germany
  24. 24. School of Health, University of the Sunshine Coast, Sunshine Coast, QLD, Australia

Source: Vox Sanguinis Published:2023


Abstract

Background and Objectives: Human neutrophil antigens (HNAs) are categorized into five systems: HNA-1 to HNA-5. Given the importance of neutrophils in immunity, we sought to create awareness of the role of HNA diagnostic services in managing immune neutropenia and transfusion-related acute lung injury. To provide health communities all around the world with access to these services, we conducted a survey to create a directory of these HNA diagnostic services. Materials and Methods: An Excel table-based survey was created to capture information on the laboratory's location and was emailed to 55 individuals with known or possible HNA investigation activity. The collected data were then summarized and analysed. Results: Of contacted laboratories, the surveys were returned from 23 (38.2%) laboratories; 17 have already established HNA diagnostic (of them 12 were regular participants of the International Granulocyte Immunobiology Workshop [ISBT-IGIW]), 4 laboratories were in the process of establishing their HNA investigation and the remaining 2 responder laboratories, did not conduct HNA investigations. In established laboratories, investigation for autoimmune neutropenia (infancies and adults) was the most frequently requested, and antibodies against HNA-1a and HNA-1b were the most commonly detected. Conclusion: The directory of survey respondents provides a resource for health professionals wanting to access HNA diagnostic services. The present study offers a comprehensive picture of HNA diagnostics (typing and serology), identifying weak points and areas for improvement for the first time. Identifying more laboratories involved in HNA diagnostics with limited access to international societies in the field will globally improve HNA diagnostics. © 2023 Institute of Clinical Immunology and Transfusion Medicine and The Authors. Vox Sanguinis published by John Wiley & Sons Ltd on behalf of International Society of Blood Transfusion.