Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share this content! On (X network) By
Feature-Tracking Cardiac Magnetic Resonance Method: A Valuable Marker of Replacement Fibrosis in Hypertrophic Cardiomyopathy Publisher



Rezaeian N1 ; Hosseini L2 ; Omidi N3 ; Khaki M1 ; Najafi H1 ; Kasani K1 ; Mousavizadeh M1 ; Khalili Y1 ; Komasi MMH4 ; Toloueitabar Y1 ; Asadian S1
Authors
Show Affiliations
Authors Affiliations
  1. 1. Rajaie Cardiovascular Medical and Research Centre, Iran University of Medical Sciences, Tehran, Iran
  2. 2. North Khorasan University of Medical Sciences, Bojnurd, Iran
  3. 3. Tehran Heart Centre (THC), Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Iran University of Medical Sciences, Tehran, Iran

Source: Polish Journal of Radiology Published:2022


Abstract

Purpose: Left ventricular (LV) replacement fibrosis is a marker of adverse cardiac events in hypertrophic cardiomyo-pathy (HCM). We aimed to assess the efficacy of the feature-tracking cardiac magnetic resonance (FT-CMR) in the detection of LV replacement fibrosis. Material and methods: Fifty-one patients with HCM (51% female, mean age = 21 ± 5.2 years) and significant myocardial hypertrophy, who underwent CMR between February 2018 and December 2019 were enrolled. Functional and 3D FT-CMR parameters were measured. LV global longitudinal strain, global radial strain (GRS), and global circum-ferential strain (GCS) were recorded. The percentage of enhanced myocardial mass was calculated. Univariate and multivariate regression analyses were performed to determine the predictors of fibrosis. A p-value of less than 0.05 was considered significant. Results: The mean enhanced mass percentage was 15.2 ± 10.53%. Among LV volumetric parameters, end-systolic and end-diastolic volume indices predicted fibrosis (fitness [F] = 8.11 and p = 0.006 vs. F = 6.6 and p = 0.012, corre-spondingly). The univariate linear regression demonstrated that GCS and GRS predicted total enhanced mass (%) (F = 12.29 and p = 0.001 vs. F = 7.92 and p = 0.007, respectively). After the inclusion of all volumetric and deforma-tion parameters, the multivariate analysis identified the model of a combination of LV end-diastolic volume index (LV EDVI) and LV GCS as a robust predictor of the fibrosis percentage (F = 8.86 and p = 0.005). Conclusions: Non-contrast CMR parameters including LV GCS and LV EDVI are valuable markers of replacement fibrosis in HCM patients with notable myocardial hypertrophy. © Pol J Radiol 2022.
Related Docs
1. Efficacy of Novel Noncontrast Cardiac Magnetic Resonance Methods in Indicating Fibrosis in Hypertrophic Cardiomyopathy, Cardiology Research and Practice (2021)
2. The Relationship of Myocardial and Liver T2*Values With Cardiac Function and Laboratory Findings in Transfusion-Dependent Thalassemia Major Patients: A Retrospective Cardiac Mri Study, Journal of Cardiovascular and Thoracic Research (2023)
3. Recommendations of the Current Guidelines for Implantable Cardioverter-Defibrillator Implantation in Patients With Hypertrophic Cardiomyopathy: Debate Still Exists, Journal of Interventional Cardiac Electrophysiology (2021)
Experts (# of related papers)
Farzad Masoud Kabir (1)
Ali Vasheghani Farahani (1)