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Repetitive Suicidal Behaviors in a Case With a New Mutation of Wolfram Syndrome: A Jump From the Gene to the Behavior Publisher



Mirfazeli FS1 ; Mohebi F2 ; Jahanbakhshi A3 ; Aryani O4, 5 ; Almasidooghaee M6
Authors
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Authors Affiliations
  1. 1. Mental Health Research Center, Psychosocial Health Research Institute, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Psychiatry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Skull Base Research Center, Department of Neurosurgery, Rasool Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Endocrinology and Metabolism Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Neuroscience, Faculty of New Medical Technologies, Iran University of Medical Sciences, Tehran, Iran
  6. 6. Department of Neurology, Firoozgar Hospital, Iran University of Medical Sciences, Tehran, Iran

Source: Basic and Clinical Neuroscience Published:2022


Abstract

Wolfram syndrome (WS) is a rare autosomal recessive neurodegenerative disease with variable symptoms, including neuropsychiatric manifestations. A 26-year-old man was reported with classic symptoms of WS and repetitive psychiatric hospitalizations and at least 16 suicidal attempts. The genetic study demonstrated a novel homozygous stop-codon mutation on the WFS1 gene. This special type of mutation may be related to repetitive suicidal behaviors in this case of WS. Psychological support should be a routine practice in patients with WS. © 2023 Istanbul Tip Fakultesi Dergisi. All rights reserved.
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