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Study of Regulatory Promoter Polymorphism (-248 G>A) of Bax Gene in Patients With Gastric Cancer in the Northern Provinces of Iran



Mirmajidi SH1 ; Najafi M2 ; Mirmajidi ST3 ; Nasrabadi NN4
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Authors Affiliations
  1. 1. College of Sciences, Sari Agricultural Sciences and Natural Resources University, Sari, Iran
  2. 2. Department of Animal Sciences and Fisheries, Sari Agricultural Sciences and Natural Resources University, Iran
  3. 3. Tehran University of Medical Sciences, Cancer Institute, Tehran, Iran
  4. 4. Mazandaran University of Medical Sciences, Sari, Iran

Source: Gastroenterology and Hepatology from Bed to Bench Published:2016

Abstract

Aim: The aim of this study is to evaluate the polymorphism in Bax gene and its association with some clinical pathology traits in gastric cancer. Background: Gastric cancer is considered as the fourth most common cancer in the north and northwest of Iran. Bcl2 family has a key role in regulation of apoptosis, and any changes in the expression of Bcl2 lead to cancer. Patients and methods: Blood samples were collected from 100 cases and 89 controls in the northern provinces of Iran to evaluate promoter polymorphism (-248G
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