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A Middle East Systematic Review and Meta-Analysis of Prevalence and Antibiotic Susceptibility Pattern in Mrsa Staphylococcus Aureus Isolated From Patients With Cystic Fibrosis Publisher Pubmed



Nikmanesh Y1 ; Foolady Azarnaminy A2 ; Avishan P3 ; Taheri M4 ; Sabeghi P5 ; Najibzadeh E6 ; Khaledi A7, 8
Authors
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Authors Affiliations
  1. 1. Gastroenterohepatology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
  2. 2. Department of Anesthesiology, Social Security Organization Hospital, Ardabil, Iran
  3. 3. Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
  4. 4. School of Medicine, Zahedan University of Medical Sciences, Zahedan, Iran
  5. 5. Shiraz University of Medical Sciences, Shiraz, Iran
  6. 6. Medical School, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Infectious Diseases Research Center, Kashan University of Medical Sciences, Kashan, Iran
  8. 8. Department of Microbiology and Immunology, School of Medicine, Kashan University of Medical Sciences, Kashan, Iran

Source: Journal of Health# Population and Nutrition Published:2022


Abstract

Background: This study aimed to determine the prevalence and antibiotic resistance patterns in Staphylococcus aureus isolated from patients with cystic fibrosis in Middle Eastern countries. Methods: A systematic search was conducted in the PubMed, Web of Science (ISI), and Scopus databases for studies presenting the prevalence of MRSA strains, antibiotic resistance pattern in S. aureus strains isolated from patients who suffered from cystic fibrosis in Middle Eastern countries from 1999 to 10 June 2020. The following terms were used; prevalence, antibiotic resistance, antimicrobial drug resistance, drug resistance, Staphylococcus aureus, S. aureus, Methicillin-resistant Staphylococcus aureus, MRSA, cystic fibrosis, CF, and the Middle East. The meta-analysis was performed using Comprehensive Meta-analysis software (Version 3.3.070). Results: Patients’ age ranged from 1.6 to 18 years. Females were more than males. The prevalence of S. aureus was varied between 5.6 and 77.8%. The prevalence of S. aureus was varied between 5.6 and 77.8% in different countries. The combined prevalence of S. aureus in Middle East countries from 1999 to 2020 was reported by 40.9% (95% CI 29.6–53.1). The pooled prevalence of MRSA was reported at 18.6% (95% CI 1.1–82.6), Z = 0.9, I2 = 98.6, Q = 146.7. The highest combined resistance in S. aureus strains was reported to Penicillin G (94%), followed by Ciprofloxacin (54.9%). Conclusion: Regarding a quite prevalence of S. aureus and an intermediate prevalence of MRSA in CF patients, preventive measures and health policies should be implemented in the Middle East area to prevent the spread of infections caused by MRSA strains in CF patients. © 2022, The Author(s).
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1. Distribution and Characteristics of Bacteria Isolated From Cystic Fibrosis Patients With Pulmonary Exacerbation, Canadian Journal of Infectious Diseases and Medical Microbiology (2022)
2. Antimicrobial Susceptibility of Microorganisms Isolated From Sputum Culture of Patients With Cystic Fibrosis: Methicillin-Resistant Staphylococcus Aureus As a Serious Concern, Microbial Pathogenesis (2016)
3. Antibiotic Susceptibility and Biofilm Formation of Bacterial Isolates Derived From Pediatric Patients With Cystic Fibrosis From Tehran, Iran, Archives of Razi Institute (2021)
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