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A New Electrochemical Sensor Based on Europium-Doped Nio Nanocomposite for Detection of Venlafaxine Publisher



Mohammadzadeh Jahani P1 ; Akbari Javar H2 ; Mahmoudimoghaddam H3, 4
Authors
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Authors Affiliations
  1. 1. School of Medicine, Bam University of Medical Sciences, Bam, Iran
  2. 2. Pharmaceutics Department, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Pharmaceutics Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Environmental Health Engineering Research Center, Kerman University of Medical Sciences, Kerman, Iran

Source: Measurement: Journal of the International Measurement Confederation Published:2021


Abstract

The present research successfully prepared the Eu3+-doped NiO modified carbon paste electrode (CPE), which has been utilized to selectively detect venlafaxine (VEN). Therefore, X-ray diffraction (XRD), scanning electron microscope (SEM) and energy-dispersive X-ray spectroscopy (EDX) have been applied for characterizing the Eu3+-doped NiO as a synthesized nanocomposite. Moreover, differential pulse voltammetry (DPV) procedure has been exploited for successfully detecting VEN. Thus, based on the optimized condition, a general linear association has been found in the experimental concentrations between 0.04 μM and 300.0 μM with 0.01 μM limit of detection (LOD) (S/N = 3). With regard to the outputs, our sensor had acceptable selectivity, significant stability, repeatability, and reproducibility. In addition, it has been substantially employed for determination of VEN in the drug and biological specimens. © 2020 Elsevier Ltd
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