Prevalence of Respiratory Viruses in Iranian Patients With Idiopathic Pulmonary Fibrosis Publisher Pubmed



Keyvani H¹ ; Moghoofei M² ; Bokharaeisalim F^{1, 3} ; Mostafaei S⁴ ; Javad Mousavi SA⁵ ; Monavari SH¹ ; Esghaei M¹ Show Affiliations
Source: Journal of Medical Microbiology Published:2017

Abstract

Introduction. Idiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal lung disease. One of the risk factors involved in the acquisition of IPF is viral infections, especially respiratory viruses. In the present study, we investigated the detection of respiratory viruses and the possible relationship between these viruses and IPF. Methods. This cross-sectional study was supported by the Iran University of Medical Sciences (IUMS), Tehran, Iran. A total of 40 respiratory samples (five nasopharyngeal and 35 bronchoalveolar lavage specimens) were obtained from IPF patients referred to IUMS hospitals between April 2015 and December 2016. Assays were performed using the CLART Pneumovir DNA array assay, which made it possible to detect five genera of respiratory viruses simultaneously. Results/Key findings. Altogether, 22 of the 40 participants were male. Respiratory syncytial virus (RSV), parainfluenza, rhino, corona and influenza viruses were found in 2.5% (1/40), 7.5% (3/40), 10% (4/40), 2.5% (1/40) and 0% (0/40) of cases, respectively. Conclusion. Determining a correlation between the viruses and IPF is not an easy task, and therefore, this will require more research. In addition, the CLART Pneumovir DNA array can be considered as a useful method for simultaneous detection of several viral respiratory infections. © 2017 The Authors.