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Cytomegalovirus Infection in a Patient With Leukocyte Adhesion Deficiency Type 1



Bahrami A1 ; Sadeghian M2 ; Sheikhvatan M3 ; Foroudi A1 ; Harsini S4, 5 ; Rezaei N4, 5, 6
Authors
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Authors Affiliations
  1. 1. Division of Immunology of Allergy, Ali-Asghar Children’s Hospital, Iran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Pediatrics, Ali-Asghar Hospital, Iran University of Medical Sciences, Tehran, Iran
  3. 3. Research and Development, Iran University of Medical Sciences, Tehran, Iran
  4. 4. Research Center for Immunodeficiencies, Children’s Medical Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA), Universal Scientific Education and Research Network (USERN), Tehran, Iran
  6. 6. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Acta Medica Iranica Published:2018

Abstract

Leukocyte adhesion deficiency type 1 (LAD-1) is a rare autosomal recessive immunodeficiency disorder, characterized by recurrent bacterial and fungal infections without pus formation. Herein, we report a case of LAD-1 that developed into gastrointestinal cytomegalovirus (CMV) disease and manifested with persistent abdominal pain and bloody diarrhea. Although the presence of concurrent gastrointestinal CMV infection with LAD-1 is a rare condition, this case highlights the need for further research to evaluate the complex mechanisms between LAD-1 and CMV occurrence. © 2018 Tehran University of Medical Sciences. All rights reserved.