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Association of Serum Uric Acid With Cardiometabolic Risk Factors and Metabolic Syndrome in Iranian Adolescents the Caspian-Iii Study Pubmed



Safiri S1, 2 ; Qorbani M3, 4 ; Heshmat R4 ; Tajbakhsh R5 ; Babaki AES4 ; Djalalinia S6, 7 ; Motlagh ME8 ; Tajadini MH9 ; Asayesh H10 ; Safari O11 ; Kelishadi R12
Authors
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Authors Affiliations
  1. 1. Managerial Epidemiology Research Center, Department of Public Health, School of Nursing and Midwifery, Maragheh University of Medical Sciences, Maragheh, Iran
  2. 2. Road Traffic Injury Research Center, Department of Statistics and Epidemiology, Tabriz University of Medical Sciences, Tabriz, Iran
  3. 3. Department of Community Medicine, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  4. 4. Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Department of Internal Medicine, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  6. 6. Noncommunicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Development of Research and Technology Center, Deputy of Research and Technology, Ministry of Health and Medical Education, Tehran, Iran
  8. 8. Department of Pediatrics, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  9. 9. Department of Biotechnology, School of Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran
  10. 10. Department of Medical Emergencies, Qom University of Medical Sciences, Qom, Iran
  11. 11. Department of Pediatrics, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
  12. 12. Department of Pediatrics, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Noncommunicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran

Source: Iranian Journal of Kidney Diseases Published:2016


Abstract

Introduction. There is controversial evidence on association of serum acid uric (SUA) with cardiometabolic risk factors and metabolic syndrome in adults. This study aimed to investigate the associations of SUA levels, components of metabolic syndrome, and other cardiometabolic risk factors, in a nationally representative sample of Iranian adolescents. Materials and Methods. This study included 132 participants who met the criteria of metabolic syndrome and 235 participants without metabolic syndrome. The participants were grouped according to the tertiles of SUA. Metabolic syndrome was defined according to the Adult Treatment Panel III criteria modified for children and adolescents. The relationship between SUA and cardiometabolic risk factors and metabolic syndrome was assessed by multivariable logistic regression analysis. Results. The mean age of the participants was 15.21 ± 2.35 years, with no significant difference between the boys and the girls. The participants whose SUA was categorized in the 2nd tertile and those falling into the 3rd tertile had significantly higher systolic blood pressure (P <.001) as compared with the lower tertile(s). A similar trend was documented for the overall high blood pressure. Metabolic syndrome was associated with the 2nd and 3rd tertiles of SUA as compared to the lower tertile(s), in the adjusted model (P <.001), with the risk increasing by at least 2 times. Conclusions. Our study showed that those adolescents with metabolic syndrome had higher SUA levels. Its association with some components of metabolic syndrome supports that SUA might be an additional component of metabolic syndrome even during adolescence. © 2016, Iranian Society of Nephrology. All rights reserved.
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