Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
C1-Functionalization of 1,2,3,4-Tetrahydroisoquinolines (Thiqs) Publisher



Tashrifi Z1 ; Mohammadi Khanaposhtani M2 ; Larijani B1 ; Mahdavi M1
Authors

Source: Asian Journal of Organic Chemistry Published:2021


Abstract

1,2,3,4-tetrahydroisoquinoline (THIQ) and its derivatives possess a widespread biochemical, pharmaceutical and biological properties and they are the key building blocks in the structure of drugs and natural alkaloids. Accordingly, construction of multi-substituted and polycyclic THIQs through functionalization of THIQs at different positions especially at C1-position have come to the center of attraction in recent studies. In this review, we've focused on the classification of C1-functionalization of THIQs in the research articles from 2013 on, including a brief description of the reaction mechanisms for the synthesis of multi-substituted and polycyclic THIQs based on the type of substituents at the 1-position of the THIQ moiety. From this point of view, the main categories are C1-Functionalization and C1-Functionalization with annulation. © 2021 Wiley-VCH GmbH
Related Docs
View other Related Docs
1. Anticancer and Anti-Inflammatory Potential of Coptisine As a Planar Quaternary Benzo[C]Phenanthridine Alkaloid With G-Quadruplex Dna Telomeric Induction Activity, Drug Development Research (2025)
2. A Simple and Efficient Procedure Toward 2-Thioxoquinazolin-4(1H)-One Derivatives, Iranian Journal of Chemistry and Chemical Engineering (2024)
3. Novel Quinazolines Bearing 1,3,4-Thiadiazole-Aryl Urea Derivative As Anticancer Agents: Design, Synthesis, Molecular Docking, Dft and Bioactivity Evaluations, BMC Chemistry (2024)
Experts (# of related papers)
View all Related Experts
Mohammad Mahdavi (9)
Bagher Larijani (6)
Other Related Docs
4. A Green and Efficient Synthesis of 2-Thioxoquinazolinone Derivatives in Water Using Potassium Thiocyanate, Journal of Sulfur Chemistry (2017)
5. Transition Metal-Catalyzed C−H Activation/Functionalization of 8-Methylquinolines, Chemical Record (2024)
6. Synthesis, in Vitro Inhibitor Screening, Structure–Activity Relationship, and Molecular Dynamic Simulation Studies of Novel Thioquinoline Derivatives As Potent Α-Glucosidase Inhibitors, Scientific Reports (2023)
7. Recent Strategies in the Synthesis of Thiophene Derivatives: Highlights From the 2012–2020 Literature, Molecular Diversity (2021)
8. Synthesis, in Vitro Α-Glucosidase Inhibitory Activities, and Molecular Dynamic Simulations of Novel 4-Hydroxyquinolinone-Hydrazones As Potential Antidiabetic Agents, Scientific Reports (2023)
9. Cubr-Catalysed One-Pot Multicomponent Synthesis of 3-Substituted 2-Thioxo-2,3-Dihydroquinazolin-4(1H)-One Derivatives, Applied Organometallic Chemistry (2019)
10. Advances and Applications of 2-Alkynylbenzaldoxime As a Valuable Synthetic Framework for Synthesizing N-Heterocycles, Tetrahedron (2023)
11. A Facile and Efficient One-Pot Procedure for the Synthesis of Novel 2-Substituted 3-Thioxoisoindolin-1-One Derivatives, Synlett (2022)
12. Design, Synthesis, and Molecular Docking Study of Novel Cinnoline Derivatives As Potential Inhibitors of Tubulin Polymerization, Zeitschrift fur Naturforschung - Section C Journal of Biosciences (2023)
13. Facile Non-Transition Metal-Catalyzed Synthesis of 2-Thioxo-2,3-Dihydroquinazolin-4(1H)-One Derivatives Via One-Pot Multicomponent Reactions, ChemistrySelect (2019)