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Henoch-Schonlein Purpura (Iga Vasculitis) in Association With Thyrotoxicosis Publisher



Sanjari M1 ; Shakibi M2 ; Safavi M3, 4
Authors
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Authors Affiliations
  1. 1. Department of Endocrinology, Afzalipour Medical Faculty and Endocrinology and Metabolism Research Center, Institute of Basic and Clinical Physiology Sciences, Kerman University of Medical Sciences, Kerman, Iran
  2. 2. Rheumatology Department, Afzalipour Medical Faculty and Physiology Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran
  3. 3. Pathology Department, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran
  4. 4. Pathology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Source: Case Reports in Endocrinology Published:2021


Abstract

Graves' disease is the most common cause of hyperthyroidism, which is characterized by thyroid antibodies and the following clinical manifestations: goiter, ophthalmopathy, and pretibial myxedema. On the other hand, Henoch-Schonlein purpura is an IgA-mediated small-vessel vasculitis. Review of the literature showed a relationship between propylthiouracil overdose and the following Henoch-Schonlein purpura (IgA vasculitis) as a side effect. The patient was a 31-year-old woman with a chief complaint of tremor and significant weight loss who contracted pruritic palpable purpura during her disease course. Then, she underwent the treatment of hyperthyroidism by methimazole which intensified her cutaneous lesions. The diagnosis of Henoch-Schonlein purpura (IgA vasculitis) was confirmed after skin biopsy. Finally, she was treated with colchicine, prednisolone, and radioiodine ablation, which caused her lesions to disappear. The temporal priority of pruritic palpable skin lesions to hyperthyroidism treatment with methimazole suggested that Henoch-Schonlein purpura (IgA vasculitis) was related to hyperthyroidism and was intensified by antithyroid agents in this patient. © 2021 Mojgan Sanjari et al.