Long Non‑Coding Rna Linc00460 Contributes As a Potential Prognostic Biomarker Through Its Oncogenic Role With Anxa2 in Colorectal Polyps

Long Non‑Coding Rna Linc00460 Contributes As a Potential Prognostic Biomarker Through Its Oncogenic Role With Anxa2 in Colorectal Polyps Publisher Pubmed

Hosseini FA¹ ; Rejali L² ; Zabihi MR³ ; Salehi Z⁴ ; Daskarabkenar E² ; Taraz T² ; Fatemi N² ; Hashemi M^{1, 5} ; Asadzadehaghdaei H² ; Nazemalhosseinimojarad E⁶

Show Affiliations

1. Department of Genetics, Faculty of Advanced Science and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran
2. Basic and Molecular Epidemiology of Gastrointestinal Disorders Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Immunology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
4. Laboratory of Complex Biological Systems and Bio-informatics (CBB), Department of Bioinformatics, Institute of Biochemistry and Biophysics (IBB), University of Tehran, Tehran, Iran
5. Farhikhtegan Medical Convergence sciences Research Centre, Farhikhtegan Hospital, Islamic Azad University, Tehran Medical Sciences, Tehran, Iran
6. Gastroenterology and Liver Diseases Research Center, Research Institute for Gastroenterology and Liver Diseases, Shahid Beheshti University of Medical Sciences, Yeman St, Chamran Expressway, 19857-17413, Tehran, Iran

Source: Molecular Biology Reports Published:2023

Abstract

Background: Long intergenic non-coding RNA 460 (LINC00460) as a potential oncogene and Annexin A2 (ANXA2) as a promoter in different cancer progression processes was considered. A significant relationship between the LINC00460 and ANXA2 has been recently discovered in colorectal cancer (CRC). Therefore, defining molecular biomarkers accompanied by lesion histopathologic features can be a suggestive prognostic biomarker in precancerous polyps. This study aimed to investigate the elusive expression pattern of ANXA2 and LINC00460 in polyps. Materials and methods: The construction of the co-expression and correlation network of LINC00460 and ANXA2 was plotted. LINC00460 and ANXA2 expression in 40 colon polyps was quantified by reverse transcription-real-time polymerase chain reaction. The receiver operating characteristic (ROC) curve was designed for distinguishing the high-risk precancerous lesion from the low-risk. Further, bioinformatics analysis was applied to find the shared MicroRNA-Interaction-Targets (MITs) between ANXA2 and LINC00460, and the associated pathways. Results: ANXA2 has a high co-expression rank with LINC00460 in the lncHUB database. Overexpression of ANXA2 and LINC00460 was distinguished in advanced adenoma polyps compared to the adjacent normal samples. The estimated AUC for ANXA2 and LINC00460 was 0.88 − 0.85 with 93%-90% sensitivity and 81%-70% specificity. In addition, eight MITs were shared between ANXA2 and LINC00460. Enrichment analysis detected several GO terms and pathways, including HIF-1α associated with cancer development. Conclusion: In conclusion, the expression of the ANXA2 and LINC00460 were significantly elevated in pre-cancerous polyps, especially in high-risk adenomas. Collectively, ANXA2 and LINC00460 may be administered as potential prognostic biomarkers in patients with a precancerous large intestine lesion as an alarming issue. © 2023, The Author(s), under exclusive licence to Springer Nature B.V.

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Experts (# of related papers)

Zahra Salehi (4)

Style	Citing Format
MLA	Hosseini FA, et al.. "Long Non‑Coding Rna Linc00460 Contributes As a Potential Prognostic Biomarker Through Its Oncogenic Role With Anxa2 in Colorectal Polyps." Molecular Biology Reports, vol. 50, no. 5, 2023, pp. 4505-4515.
APA	Hosseini FA, Rejali L, Zabihi MR, Salehi Z, Daskarabkenar E, Taraz T, Fatemi N, Hashemi M, Asadzadehaghdaei H, Nazemalhosseinimojarad E (2023). Long Non‑Coding Rna Linc00460 Contributes As a Potential Prognostic Biomarker Through Its Oncogenic Role With Anxa2 in Colorectal Polyps. Molecular Biology Reports, 50(5), 4505-4515.
Chicago	Hosseini FA, Rejali L, Zabihi MR, Salehi Z, Daskarabkenar E, Taraz T, Fatemi N, Hashemi M, Asadzadehaghdaei H, Nazemalhosseinimojarad E. "Long Non‑Coding Rna Linc00460 Contributes As a Potential Prognostic Biomarker Through Its Oncogenic Role With Anxa2 in Colorectal Polyps." Molecular Biology Reports 50, no. 5 (2023): 4505-4515.
Harvard	Hosseini FA et al. (2023) 'Long Non‑Coding Rna Linc00460 Contributes As a Potential Prognostic Biomarker Through Its Oncogenic Role With Anxa2 in Colorectal Polyps', Molecular Biology Reports, 50(5), pp. 4505-4515.
Vancouver	Hosseini FA, Rejali L, Zabihi MR, Salehi Z, Daskarabkenar E, Taraz T, et al.. Long Non‑Coding Rna Linc00460 Contributes As a Potential Prognostic Biomarker Through Its Oncogenic Role With Anxa2 in Colorectal Polyps. Molecular Biology Reports. 2023;50(5):4505-4515.
BibTex	@article{ author = {Hosseini FA and Rejali L and Zabihi MR and Salehi Z and Daskarabkenar E and Taraz T and Fatemi N and Hashemi M and Asadzadehaghdaei H and Nazemalhosseinimojarad E}, title = {Long Non‑Coding Rna Linc00460 Contributes As a Potential Prognostic Biomarker Through Its Oncogenic Role With Anxa2 in Colorectal Polyps}, journal = {Molecular Biology Reports}, volume = {50}, number = {5}, pages = {4505-4515}, year = {2023} }
RIS	TY - JOUR AU - Hosseini FA AU - Rejali L AU - Zabihi MR AU - Salehi Z AU - Daskarabkenar E AU - Taraz T AU - Fatemi N AU - Hashemi M AU - Asadzadehaghdaei H AU - Nazemalhosseinimojarad E TI - Long Non‑Coding Rna Linc00460 Contributes As a Potential Prognostic Biomarker Through Its Oncogenic Role With Anxa2 in Colorectal Polyps JO - Molecular Biology Reports VL - 50 IS - 5 SP - 4505 EP - 4515 PY - 2023 ER -

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