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Association Between Matrix Metaloproteinases 2-1306C/T Polymorphism and the Risk of Coronary Artery Disease in Iranian Population Publisher



Sattari M1 ; Hassanzad M2 ; Jamaldini SH1 ; Najafi A3 ; Imani M1 ; Mohammadhassani M3 ; Hasanzad M4, 5
Authors
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Authors Affiliations
  1. 1. Medical Genomics Research Center, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  2. 2. Pediatric Respiratory Disease Research Center, NRITLD, Masih Daneshvari Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran
  3. 3. Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  4. 4. Department of Genetics, Tehran Medical Sciences Branch, Islamic Azad University, Tehran, Iran
  5. 5. Personalized Medicine Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran

Source: Pathophysiology Published:2017


Abstract

Background Coronary Artery Disease (CAD) represents the most important cause of sudden cardiac death. Interaction between genetic and environmental factors, individual susceptibility of the development of CAD is one of the MMP2 genes. Genetic variants’ dysfunction of the MMP2 gene associated with the risk of CAD. The aim of the present study is to assess possible association between risk of Coronary Artery Disease and MMP2-1306C/T polymorphism. Methods This case-control study contains a total number of 344 subjects, including 215 patients with CAD and 129 of controls. Genomic DNA was isolated from whole blood and genotyping was performed by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR- RFLP) method. Results This study reveals the result that about 3.5% of CAD patients had TT genotype while 30.4% of them had CT genotype. Corresponding figures for subjects without CAD were zero and 52.6% respectively. These differences were statistically significant (P = 0.002). Frequencies of T allele among patients with and without CAD were 18.71% and 26.28% respectively (p = 0.04). The odds ratio between T allele and CAD was 0.64 (p = 0.055). we couldn't trace significant differences among alleles in Gensini score, Gesnsini score's median among patients carried out TT, CT and CC genotypes were 4, 2 and 2 respectively (p = 0.3). Conclusions Result of this study provides some evidences that the MMP2-1306 polymorphism can be associated with coronary artery disease. Further longitudinal studies including more sample sizes are required to confirm this protective effect. © 2017
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