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Prognostic Value of Serum Amyloid a Protein As a Biomarker in the Diagnosis of 2019 Novel Coronavirus Disease (Covid-19) Publisher Pubmed



Amini R1 ; Mosadegh M2 ; Ansari N3 ; Banaye Golrizi M4 ; Bashirian S5 ; Erfani Y6 ; Khazaei S7 ; Azizi Jalilian F1, 3
Authors
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Authors Affiliations
  1. 1. Research Center for Molecular Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  2. 2. Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Department of Virology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
  4. 4. Department of Molecular Virology, Farzan Molecular and Pathobiology Laboratory, Hamadan, Iran
  5. 5. Department of Public Health, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran
  6. 6. Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran
  7. 7. Department of Epidemiology, School of Health, Hamadan University of Medical Sciences, Hamadan, Iran

Source: Microbial Pathogenesis Published:2024


Abstract

Background: The current study aimed to evaluate the prognostic value of serum amyloid A protein)SAA(protein as a biomarker in diagnosing 2019 novel coronavirus disease)COVID-19(infection. Methods: The study was conducted on 123 patients with definitive COVID-19 infection referred to Shahid Beheshti and Sina hospitals in Hamedan province, Iran. Five-milliliter blood samples were taken from all included patients and serum was isolated using a centrifuge at 10,000 rpm for 10 min. Laboratory tests were conducted, including c-reactive protein (CRP), Erythrocyte Sedimentation Rate (ESR), potassium level, sodium blood test, platelets (PLT), complete blood count (CBC), lymphocyte count, and neutrophil count. The SAA enzyme-linked immunosorbent assay (ELISA) Kit was applied to measure the SAA level in serum samples. Results: 123 patients included 73 males and 50 females, age ±50. Sixty-six (53.7 %) patients had negative CRP while 80 (65 %) patients had normal ESR. Potassium levels were not normal among 111 (94.9 %) patients. Seventy-seven (63.1 %) patients had normal CBC, while 108 (87.8 %) patients had neutrophils above the normal range. 94 (97.9 %) patients over the age of 50 were positive for SAA. In terms of gender, men were the most frequent patients with SAA. There was a statistically significant relationship between the serum level of SAA and outcomes of patients with COVID-19 (p = 0.0001). 94 % of patients with SAA ≤50 were recovered from COVID-19 infection. The sensitivity rate of SAA compared to polymerase chain reaction (PCR) and computed tomography scan (CT scan) tests was 93 % and 99 %, respectively. Moreover, the accuracy of SAA compared to PCR and CT scan tests was 52 % and 96 %, respectively. Conclusion: Results indicate the SAA is a sensitive, but not specific biomarker in the early detection of COVID-19. The quantitative levels of SAA can be useful in predicting treatment outcomes among patients with COVID-19. © 2024
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