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Premature Coronary Artery Disease Is More Prevalent in People Who Go to Bed Late Publisher Pubmed



Masoudkabir F1, 2 ; Mohammadi Z3 ; Alirezaei M4 ; Cheraghian B5 ; Rahimi Z6 ; Roayaei P1 ; Naderian MR7 ; Danehchin L8 ; Paridar Y9 ; Abolnezhadian F10, 11 ; Vasheghanifarahani A1, 2 ; Noori M12 ; Mard SA13 ; Masoudi S3 Show All Authors
Authors
  1. Masoudkabir F1, 2
  2. Mohammadi Z3
  3. Alirezaei M4
  4. Cheraghian B5
  5. Rahimi Z6
  6. Roayaei P1
  7. Naderian MR7
  8. Danehchin L8
  9. Paridar Y9
  10. Abolnezhadian F10, 11
  11. Vasheghanifarahani A1, 2
  12. Noori M12
  13. Mard SA13
  14. Masoudi S3
  15. Shayesteh AA13
  16. Poustchi H3
Show Affiliations
Authors Affiliations
  1. 1. Cardiac Primary Prevention Research Center, Cardiovascular Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  2. 2. Department of Cardiology, Tehran Heart Center, Tehran University of Medical Sciences, Tehran, Iran
  3. 3. Liver and Pancreatobiliary Diseases Research Center, Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran
  4. 4. Students' Scientific Research Center, Tehran University of Medical Sciences, Tehran, Iran
  5. 5. Alimentary Tract Research Center, Clinical Sciences Research Institute, Department of Biostatistics and Epidemiology, School of Public Health, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  6. 6. Department of Epidemiology, School of Public Health Iran University of Medical Sciences, Tehran, Iran
  7. 7. Non-Communicable Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
  8. 8. Behbahan Faculty of Medical Sciences, Behbahan, Iran
  9. 9. School of Medicine, Dezful University of Medical Sciences, Dezful, Iran
  10. 10. Shoushtar Faculty of Medical Sciences, Shoushtar, Iran
  11. 11. Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
  12. 12. Abadan Faculty of Medical Sciences, Abadan, Iran
  13. 13. Alimentary Tract Research Center, Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Source: Archives of Iranian Medicine Published:2021


Abstract

Background: Little is known regarding the impact of quantity and quality of sleep on the incidence of cardiovascular disease. The aim of this study was to investigate the possible independent association of late bedtime and premature coronary artery disease (PCAD). Methods: Between October 2016 and November 2019, we conducted a cross-sectional population-based study on 30 101 participants aged 20-65 years in Khuzestan Comprehensive Health Study (KCHS). Data on major risk factors of cardiovascular disease, habit history, physical activity, and sleep behavior was gathered and participants underwent blood pressure, anthropometric, and serum lipid and glucose profile measurements. PCAD was defined as documented history of developing obstructive coronary artery disease before 45 years in men and before 55 years in women. Results: Of a total of 30 101 participants (64.1% female, mean age: 41.7 ± 11.7 years) included in this study, 1602 (5.3%, 95% confidence interval: 5.1%-5.6%) had PCAD. Late bedtime was reported in 7613 participants (25.3%, 95% confidence interval: 24.9%-25.8%). Age-sex standardized prevalence for PCAD and late bedtime were 3.62 (3.43-3.82) and 27.8 (27.2-28.4), respectively. There was no significant difference (P = 0.558) regarding prevalence of PCAD between those with late bedtime (5.5%, 95% CI: 4.9%-6.0%) and those with early bedtime (5.3%, 95% CI: 5.0%-5.6%). However, after adjustment for potential confounders, late bedtime was independently associated with PCAD (OR = 1.136, 95% CI = 1.002-1.288, P = 0.046). Conclusion: In this study, late bedtime was significantly associated with presence of PCAD. Future prospective studies should elucidate the exact role of late bedtime in developing coronary atherosclerosis prematurely. © 2021 Academy of Medical Sciences of I.R. Iran. All rights reserved.
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