Prevalence of Diabetes-Associated Autoantibodies Among Patients Presenting With Type 2 Diabetes and Related Metabolic Differences

Prevalence of Diabetes-Associated Autoantibodies Among Patients Presenting With Type 2 Diabetes and Related Metabolic Differences Publisher Pubmed

Moosaie F¹ ; Meftah N¹ ; Deravi N^{1, 2} ; Abouhamzeh K¹ ; Firouzabadi FD¹ ; Khaloo P¹ ; Mansournia MA³ ; Fatemi Abhari SM⁴ ; Nakhjavani M¹ ; Esteghamati A¹

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1. Endocrinology and Metabolism Research Center (EMRC), Vali-Asr Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
2. Student's Research committee, School of medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
3. Department of Epidemiology and Biostatistics, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
4. Department of Pediatrics, Imam Ali Hospital, Alborz University of Medical Sciences, Iran

Source: Primary Care Diabetes Published:2021

Abstract

Background: To explores the prevalence of autoantibodies (zinc transporter 8 autoantibodies (ZnT8A), antibodies to insulin (IAAs), glutamic acid decarboxylase autoantibody (GAD65)), the relation of the type of positive autoantibody and the number of positive autoantibodies with the glycemic and lipid profile of the patients with LADA (Latent Autoimmune Diabetes in Adults) and compares it to the metabolic profile of patients presenting with type 2 diabetes (T2DM). Methods: 263 patients with T2DM were recruited for this cross-sectional study in Tehran, Iran. Data from patients included complete medical history, GAD65, ZnT8A, IAA and routine metabolic laboratory workup. Assay for autoantibodies were conducted using ELISA kits. The association between autoantibodies and glycemic and lipid profile of patients with diabetes was assessed using univariate and multivariate regression analysis. Results: Our study revealed that among 263 patients with T2DM, 29 (11%) cases were positive for IAAs, 9 (3.4%) for ZnT8A, and 12 (4.6%) for GAD65. Six (2.3%) of the patients had triple positive antibodies. Patients with positive results were younger, had lower body mass index (BMI), c-peptide, triglyceride, low-density lipoprotein (LDL), and higher high-density lipoprotein (HDL), HbA1c and fasting blood glucose (FBG) levels. Triple antibody positivity was significantly associated with lower levels of C-Peptide, Triglycerides, FBG, and HbA1c compared to triple negative antibodies. Conclusion: Patients with LADA positive for either of the autoantibodies (GAD65, ZnT8 and IAA) presented with worse glycemic control. Measurement of these autoantibodies can assist in discrimination of these patients and help with earlier control of glycemic profile. © 2020 Primary Care Diabetes Europe

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Style	Citing Format
MLA	Moosaie F, et al.. "Prevalence of Diabetes-Associated Autoantibodies Among Patients Presenting With Type 2 Diabetes and Related Metabolic Differences." Primary Care Diabetes, vol. 15, no. 1, 2021, pp. 169-174.
APA	Moosaie F, Meftah N, Deravi N, Abouhamzeh K, Firouzabadi FD, Khaloo P, Mansournia MA, Fatemi Abhari SM, Nakhjavani M, Esteghamati A (2021). Prevalence of Diabetes-Associated Autoantibodies Among Patients Presenting With Type 2 Diabetes and Related Metabolic Differences. Primary Care Diabetes, 15(1), 169-174.
Chicago	Moosaie F, Meftah N, Deravi N, Abouhamzeh K, Firouzabadi FD, Khaloo P, Mansournia MA, Fatemi Abhari SM, Nakhjavani M, Esteghamati A. "Prevalence of Diabetes-Associated Autoantibodies Among Patients Presenting With Type 2 Diabetes and Related Metabolic Differences." Primary Care Diabetes 15, no. 1 (2021): 169-174.
Harvard	Moosaie F et al. (2021) 'Prevalence of Diabetes-Associated Autoantibodies Among Patients Presenting With Type 2 Diabetes and Related Metabolic Differences', Primary Care Diabetes, 15(1), pp. 169-174.
Vancouver	Moosaie F, Meftah N, Deravi N, Abouhamzeh K, Firouzabadi FD, Khaloo P, et al.. Prevalence of Diabetes-Associated Autoantibodies Among Patients Presenting With Type 2 Diabetes and Related Metabolic Differences. Primary Care Diabetes. 2021;15(1):169-174.
BibTex	@article{ author = {Moosaie F and Meftah N and Deravi N and Abouhamzeh K and Firouzabadi FD and Khaloo P and Mansournia MA and Fatemi Abhari SM and Nakhjavani M and Esteghamati A}, title = {Prevalence of Diabetes-Associated Autoantibodies Among Patients Presenting With Type 2 Diabetes and Related Metabolic Differences}, journal = {Primary Care Diabetes}, volume = {15}, number = {1}, pages = {169-174}, year = {2021} }
RIS	TY - JOUR AU - Moosaie F AU - Meftah N AU - Deravi N AU - Abouhamzeh K AU - Firouzabadi FD AU - Khaloo P AU - Mansournia MA AU - Fatemi Abhari SM AU - Nakhjavani M AU - Esteghamati A TI - Prevalence of Diabetes-Associated Autoantibodies Among Patients Presenting With Type 2 Diabetes and Related Metabolic Differences JO - Primary Care Diabetes VL - 15 IS - 1 SP - 169 EP - 174 PY - 2021 ER -

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